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Cystatin C and uncontrolled hypertension [Anatol J Cardiol]
Anatol J Cardiol. 2020; 24(5): 309-315 | DOI: 10.14744/AnatolJCardiol.2020.78974  

Cystatin C and uncontrolled hypertension

Mehmet Onur Omaygenç, Özgür Ulaş Özcan, Beytullah Çakal, Oğuz Karaca
Department of Cardiology, Faculty of Medicine, İstanbul Medipol University; İstanbul-Turkey

Objective: Increased serum level of cystatin C, a sensitive biomarker for renal function, seems to predict adverse cardiovascular events. We investigated the predictive value of serum cystatin C for controlling hypertension in an observational study.
Methods: We screened 1037 adults residing in both rural and urban communities. They were grouped based on their diagnosis and control of hypertension.
Results: Serum cystatin C levels in patients with uncontrolled hypertension were higher than those in patients with controlled hypertension (0.98±0.23 mg/L vs. 0.89±0.19 mg/L, p=0.001). However, serum creatinine levels were similar between these groups (0.72±0.20 mg/dL vs. 0.70±0.18 mg/dL, p=0.89). Serum cystatin C levels increased the probability of uncontrolled hypertension independent from confounding factors (odds ratio, 1.48; 95% confidence interval, 1.09–5.64; p=0.03).
Conclusion: Subtle kidney dysfunction may be detected using serum cystatin C concentrations among patients with poor blood pressure control and normal serum creatinine levels.

Keywords: chronic kidney disease, creatinine, cystatin C, hypertension


Mehmet Onur Omaygenç, Özgür Ulaş Özcan, Beytullah Çakal, Oğuz Karaca. Cystatin C and uncontrolled hypertension. Anatol J Cardiol. 2020; 24(5): 309-315

Corresponding Author: Mehmet Onur Omaygenç, Türkiye


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