ISSN 2149-2263 | E-ISSN 2149-2271
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Evaluation of Tp–e interval, Tp–e/QT ratio, and Tp–e/QTc ratio in patients with Behçet’s disease [Anatol J Cardiol]
Anatol J Cardiol. 2019; 22(2): 85-90 | DOI: 10.14744/AnatolJCardiol.2019.70019

Evaluation of Tp–e interval, Tp–e/QT ratio, and Tp–e/QTc ratio in patients with Behçet’s disease

Şıho Hidayet1, Vahit Demir2, Yaşar Turan2, Gülhan Gürel3, Mehmet Hakan Taşolar1
1Department of Cardiology, Faculty of Medicine, İnönü University; Malatya-Turkey
2Department of Cardiology, Faculty of Medicine, Bozok University, Yozgat-Turkey
3Department of Dermatology, Faculty of Medicine, Bozok University, Yozgat-Turkey

Objective: Behçet's disease (BD), a multisystemic inflammatory disorder, has been associated with a number of cardiovascular dysfunctions, including ventricular arrhythmias and sudden cardiac death. The mechanism of increased ventricular arrhythmias in BD remains uncertain. The aim of the present study was to assess the ventricular repolarization by using the Tp–e interval, Tp–e/QT ratio, and Tp–e/QTc ratio as candidate markers of ventricular arrhythmias in patients with BD.
Methods: A total of 42 patients (mean age: 42.71±10.99 years) with BD and 50 sex- and age-matched healthy volunteers (mean age: 39.24±11.32 years) as the control group were evaluated. The risk of ventricular arrhythmia was evaluated by calculating the electrocardiographic, the Tp–e interval, and the QT, QTc, Tp e/QT, and Tp–e/QTc ratios.
Results: QTmax (p=0.005), QTcmax (p=0.015), QTmin (p=0.011), and QTcmin (p=0.024) were statistically significantly higher in the BD group than in the control group. The Tp–e, cTp–e, Tp–e/QT, and Tp–e/QTc ratios were also significantly higher in patients with BD than in the control group (80.26±4.55 and 74.74±6.47, respectively, p<0.001; 88.23±6.36 and 82.68±7.81, respectively, p<0.001; 0.21±0.01 and 0.20±0.01, respectively, p=0.008; and 0.19±0.01 and 0.18±0.01, respectively, p=0.01). Positive correlations were found between Tp–e/QTc ratio and disease duration (r=0.382, p=0.013).
Conclusion: Our study showed that the Tp–e interval, Tp–e/QT ratio, and Tp–e/QTc ratio, which are evaluated electrocardiographically in patients with BD, have been prolonged compared with normal healthy individuals. A positive correlation was determined between disease duration and Tp–e/QTc ratio. These results may be indicative of an early subclinical cardiac involvement in patients with BD, considering the duration of the disease. Therefore, these patients should be more closely screened for ventricular arrhythmias.

Keywords: Behçet’s disease, Tp–e interval, Tp–e/QTd ratio, ventricular arrhythmia

Şıho Hidayet, Vahit Demir, Yaşar Turan, Gülhan Gürel, Mehmet Hakan Taşolar. Evaluation of Tp–e interval, Tp–e/QT ratio, and Tp–e/QTc ratio in patients with Behçet’s disease. Anatol J Cardiol. 2019; 22(2): 85-90

Corresponding Author: Şıho Hidayet, Türkiye
Manuscript Language: English


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