ISSN 2149-2263 | E-ISSN 2149-2271
pdf
The serial changes in plasma homocysteine levels and it’s relationship with acute phase reactants in early postmyocardial infarction period [Anatol J Cardiol]
Anatol J Cardiol. 2005; 5(1): 8-12

The serial changes in plasma homocysteine levels and it’s relationship with acute phase reactants in early postmyocardial infarction period

Murat Sucu1, Abdulaziz Karadede1, Gülten Toprak2, Nizamettin Toprak3
1Department of Cardiology, Faculty of Medicine, Dicle University, Diyarbakır, Turkey
2Department of Biochemistry, Faculty of Medicine, Dicle University, Diyarbakır, Turkey
3Dicle Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, Diyarbakır, Türkiye

Objective: We aimed to study the change in the plasma homocysteine concentration in the early stage of acute myocardial infarction and its relationship with the acute phase reactants. Methods: We included into the study 33 patients who were admitted to the hospital with acute myocardial infarction within the first three hours after the onset of symptoms. The plasma samples were obtained on admission (within 3 hours onset of symptom) and at 6, 12, 24 hours and 2, 4, 7, 30 and 90th day after admission. Results: The serial homocysteine measurements were as following: 11.87±0.71 µmol/L, 11.89±0.62 µmol/L, 11.37±0.83 µmol/L, 10.96±0.93 µmol/L, 11.37 ±0.89 µmol/L, 11.24±0.66 µmol/L, 13.09±0.64 µmol/L, 12.85±0.71 µmol/L and 12.19±0.91 µmol/L respectively (p=0.05). Statistically significant difference was found only between the hour 24 and the day 7 (p=0.04). However, there was no statistically significant difference between the admission level and none of the other time points. No correlation was identified between acute phase reactants and lipid parameters that were measured serially at the same time periods and homocysteine levels. Conclusion: Although homocysteine plasma values obtained during the sixth and twelfth hours of acute myocardial infarction provide reliable results as a risk markers, timing of blood sampling during the myocardial infarction does not have significant role since plasma values of homocysteine did not affect acute phase reactants.

Keywords: Acute myocardial infarction, homocysteine, acute phase reactants

Murat Sucu, Abdulaziz Karadede, Gülten Toprak, Nizamettin Toprak. The serial changes in plasma homocysteine levels and it’s relationship with acute phase reactants in early postmyocardial infarction period. Anatol J Cardiol. 2005; 5(1): 8-12
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

Quick Search



Copyright © 2024 The Anatolian Journal of Cardiology



Kare Publishing is a subsidiary of Kare Media.