The Anatolian Journal of Cardiology
Original Investigation

Is the neutrophil-to-lymphocyte ratio indicative of inflammatory state in patients with obesity and metabolic syndrome?

1.

Department of Biophysics, Faculty of Medicine, Düzce University, Düzce-Turkey

2.

Department of Family Medicine, Faculty of Medicine, Düzce University, Düzce-Turkey

3.

Family Health Center, Düzce-Turkey

4.

Departments of Cardiology, Faculty of Medicine, Düzce University, Düzce-Turkey

5.

Department of Family Medicine, University Ss Cyril and Metodius, Medical Faculty, Skopje 1109 R-Macedonia

6.

Department of Cardiology, Faculty of Medicine, Abant İzzet Baysal University, Bolu-Turkey

Anatol J Cardiol 2015; 15: 816-822
DOI: 10.5152/akd.2014.5787
Read: 133 Downloads: 93 Published: 01 July 2021

Objective: Obesity causes subclinical inflammation. Leukocyte count and high-sensitivity C-reactive protein (hs-CRP) are used to indicate inflammation in clinical practice. Also, inflammatory markers are evaluated as important indicators of cardiovascular risk in patients with obesity and metabolic syndrome (MetS). We aimed to investigate the usage of the neutrophil-lymphocyte ratio (NLR) as an inflammatory marker in obese patients with and without MetS. Methods: The study included a total of 1267 patients. The patients were assigned groups according to degree of obesity and status of MetS. Metabolic and inflammatory markers were compared between groups, and correlation analysis was performed. Results: Leukocyte count and hs-CRP were significantly different (p<0.001), but NLR was not different between body mass index (BMI) groups (p=0.168). Both lymphocyte and neutrophil counts were significantly increased with increased degree of obesity (p<0.001, p=0.028, respectively). Leukocyte, neutrophil, and lymphocyte counts and hs-CRP level showed a significant correlation with BMI (r=0.198, p<0.001; r=0.163, p<0.001; r=0.167, p<0.001; r=0.445, p<0.001, respectively), whereas NLR was not correlated with BMI (r=0.017, p=0.737). Only a significant association between a MetS severity of 5 and 4 with hs-CRP level was observed (p=0.028), whereas there was no statistically significant association for leukocyte count and NLR (p=0.246; p=0.643, respectively). Conclusion: NLR was not a good indicator of inflammation, while leukocyte and hs-CRP were more useful biomarkers to indicate inflammation in non-diabetic patients with obesity and MetS.

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ISSN 2149-2263 EISSN 2149-2271