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The Anatolian Journal of Cardiology Could decreased vitamin D levels be related with impaired cardiac autonomic functions in patients with chronic heart failure: an observational study [Anatol J Cardiol]
Anatol J Cardiol. 2014; 14(5): 434-441 | DOI: 10.5152/akd.2014.4869  

Could decreased vitamin D levels be related with impaired cardiac autonomic functions in patients with chronic heart failure: an observational study

Metin Çetin1, Güliz Kozdağ2, Dilek Ural1, Göksel Kahraman1, İrem Yılmaz1, Yaşar Akay2, Raşit Onuk2, Nigar Dursun3
1Clinic of Cardiology, Çerkezköy State Hospital; Tekirdağ-Turkey
2Department of Cardiology, Faculty of Medicine, Kocaeli University; Kocaeli-Turkey
3Department of Physical Medicine and Rehabilitation, Faculty of Medicine, Kocaeli University; Kocaeli-Turkey

Objective: Vitamin D status has been implicated in the pathophysiology of heart failure (HF). The aim of this study was to investigate the association between vitamin D levels with heart rate variability and heart rate turbulence in patients with heart failure whom had ischemic and non-ischemic dilated cardiomyopathy. Methods: Study designed as an observational cross-sectional study. Seventy-one patients [36 non-ischemic dilated cardiomyopathy (NIDCM), 35 ischemic dilated cardiomyopathy (IDCM)] with chronic heart failure and 25 control subject were included It was evaluated the association between 25 hydroxyvitamin D [25(OH)D] and calcitriol levels with heart rate variability time domain (SDNN, SDANN, RMSSD) and heart rate turbulence [turbulence onset (TO), turbulence slope (TS)] parameters. Statistical analysis was performed using Kruskal-Wallis test and ANOVA. Results: Calcitriol levels in NIDCM patients with abnormal TO and TS were significantly lower than NIDCM patients with normal TO (17.1±11.3 vs 27.6±15.5 pg/mL, p=0.05) and TS (16.6±9.1 vs 29.4±16.9 pg/mL, p=.018). There was a positive correlation between 25 (OH) D with heart rate variability parameters SDNN (r=0.368, p=0.027) and SDANN (r=0.360, p=0.031). It was not found any association between vitamin D and parameters of heart rate variability and heart rate turbulence in IDCM patients. Conclusion: Insufficiency of vitamin D may have deleterious effects on cardiac autonomic functions which were showed with heart rate turbulence and heart rate variability in patients with NIDCM. Vitamin D levels might be a predictor to determine the sudden cardiac death in patients with non-ischemic etiology.

Keywords: 25 hydroxy vitamin D, calcitriol, dilated cardiomyopathy, heart rate variability, heart rate turbulence, sudden cardiac death


Metin Çetin, Güliz Kozdağ, Dilek Ural, Göksel Kahraman, İrem Yılmaz, Yaşar Akay, Raşit Onuk, Nigar Dursun. Could decreased vitamin D levels be related with impaired cardiac autonomic functions in patients with chronic heart failure: an observational study. Anatol J Cardiol. 2014; 14(5): 434-441


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