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The Anatolian Journal of Cardiology Beat-to-beat variability of repolarization: a new parameter to determine arrhythmic risk of an individual or identify proarrhythmic drugs [Anatol J Cardiol]
Anatol J Cardiol. 2007; 7(Suppl 1): 73-78

Beat-to-beat variability of repolarization: a new parameter to determine arrhythmic risk of an individual or identify proarrhythmic drugs

Peter Oosterhoff1, Avram Oros2, Marc A. Vos3
1Bakken Research Center, Medtronic, Maastricht
2From the Department of Medical Physiology, Heart Lung Centre Utrecht, UMC Utrecht, Utrecht the Netherlands
3Department of Cardiology, Academic Hospitol Maastrich & Cardivascular Research Institute Maastricht, The Netherlands

Hypertrophy and heart failure are associated with an enhanced propensity for cardiac arrhythmias and a high mortality rate. Altered repolarization might play a role in the occurrence of these ventricular arrhythmias. Beat-to-beat variability of repolarization duration (BVR) has been proposed as a parameter for detection of an unstable, and less controlled repolarization process that precedes the actual tachyarrhythmia. To investigate the relevance of BVR in identifying individuals at risk for arrhythmic events, this parameter was studied in dogs with remodeled hearts and increased susceptibility to arrhythmias due to chronic complete atrioventricular block. Progression of electrical remodeling (prolongation of repolarization times), vulnerability to arrhythmias and sudden cardiac death were reflected in baseline values of BVR. Furthermore, BVR showed a strong predictive value in the screening for pro-arrhythmic effects of drugs. Thus, BVR can be used to identify 1) individuals at risk for ventricular tachycardias and 2) drugs with proarrhythmic properties.

Keywords: Ventricular repolarization, Torsade de Pointes, arrhythmias, electrophysiology


Peter Oosterhoff, Avram Oros, Marc A. Vos. Beat-to-beat variability of repolarization: a new parameter to determine arrhythmic risk of an individual or identify proarrhythmic drugs. Anatol J Cardiol. 2007; 7(Suppl 1): 73-78


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