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The Anatolian Journal of Cardiology Association between baseline cardiovascular mechanics and exercise capacity in patients with coronary artery disease [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(8): 608-613 | DOI: 10.5152/AnatolJCardiol.2015.6471  

Association between baseline cardiovascular mechanics and exercise capacity in patients with coronary artery disease

Emre Aslanger1, Benjamin Assous2, Nicolas Bihry2, Florence Beauvais3, Damien Logeart3, Alain Cohen-solal3
1Department Of Cardiology, School Of Medicine, Koç University, Ýstanbul- Turkey
2Department Of Cardiology, Lariboisière Hospital, Assistance Publique-hôpitaux De Paris (ap-hp), Paris- France
3Umr-s 942, Université Paris Diderot, Dhu Fýre, Department Of Cardiology, Lariboisière Hospital, Assistance Publique-hôpitaux De Paris, (ap-hp) Paris- France

Objective: Functional capacity is one of the cardinal determinants of morbidity and mortality in patients with coronary artery disease (CAD). We hypothesized that baseline cardiovascular mechanics, including cardiac systolic and diastolic functions, arterial mechanics, and ventriculoarterial interaction, may play a role in predicting exercise capacity in patients with CAD.
Methods: Fifty consecutive patients with CAD who were referred to cardiac rehabilitation were prospectively included in the study. Patients with non-sinus rhythms or severe valvular disease were excluded. Full left ventricular pressure–volume loops were constructed and arterial mechanics was evaluated using echocardiographic and tonometric measurements. Cardiopulmonary exercise tests were performed to measure exercise capacity.
Results: Fifty patients were enrolled in the study. Ventriculo-arterial coupling showed a moderate correlation with peak oxygen consumption (VO2) (r=0.410, p=0.04) in patients with reduced left ventricular ejection fraction (LVEF). Only left ventricular volume at 15 mm Hg (r=0.514, p<0.01) in diastolic parameters (stiffness constant, p=0.75; ventricular compliance, p=0.17) and arterial compliance (r=0.467, p=0.01) in arterial parameters [arterial elastance, p=0.27; systemic vascular resistance, p=0.45; augmentation pressure, p=0.85; augmentation index (AIx), p=0.63; heart rate-corrected AIx, p=0.68] emerged as significant factors correlated with peak VO2 in patients with normal LVEF.
Conclusion: Comprehensive evaluation of resting cardiovascular mechanics can give clues about exercise-recruited reserves of the cardiovascular system. Optimization of ventriculo-arterial coupling in patients with reduced LVEF and arterial compliance in patients with normal LVEF should be the main target in patients with CAD and limited functional capacity. (Anatol J Cardiol 2016; 16: 000-00)

Keywords: arterial compliance, cardiopulmonary exercise test, coronary artery disease, functional capacity, pressure–volume loop


Emre Aslanger, Benjamin Assous, Nicolas Bihry, Florence Beauvais, Damien Logeart, Alain Cohen-solal. Association between baseline cardiovascular mechanics and exercise capacity in patients with coronary artery disease. Anatol J Cardiol. 2016; 16(8): 608-613

Corresponding Author: Emre Aslanger, Türkiye


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