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Anatol J Cardiol: 21 (5)
Volume: 21  Issue: 5 - May 2019
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EDITORIAL
1.ESC Editors Network consensus report and new studies
Çetin Erol
PMID: 31062757  doi: 10.14744/AnatolJCardiol.2019.5  Page 241
Abstract | Full Text PDF

ORIGINAL INVESTIGATION
2.Gender disparities in heart failure with mid-range and preserved ejection fraction: Results from APOLLON study
Bülent Özlek, Eda Özlek, Serkan Kahraman, Mehmet Tekinalp, Hicaz Zencirkiran Agus, Oğuzhan Çelik, Cem Çil, Volkan Doğan, Özcan Başaran, Bedri Caner Kaya, Ibrahim Rencüzoğulları, Altuğ Ösken, Lütfü Bekar, Ozan Çakır, Yunus Çelik, Kadir Uğur Mert, Kadriye Memiç Sancar, Samet Sevinç, Gurbet Özge Mert, Murat Biteker
PMID: 31062760  doi: 10.14744/AnatolJCardiol.2019.71954  Pages 242 - 252
Objective: This study aimed to examine gender-based differences in epidemiology, clinical characteristics, and management of consecutive patients with heart failure with mid-range ejection fraction (HFmrEF) and heart failure with preserved ejection fraction (HFpEF).
Methods: The APOLLON trial (A comPrehensive, ObservationaL registry of heart faiLure with mid-range and preserved ejection fractiON) is a multicenter, cross-sectional, and observational study. Consecutive patients with HFmrEF or HFpEF who were admitted to the cardiology clinics were included (NCT03026114). Herein, we performed a post-hoc analysis of data from the APOLLON trial.
Results: The study population included 1065 (mean age of 67.1±10.6 years, 54% women) patients from 11 sites in Turkey. Compared with men, women were older (68 years vs. 67 years, p<0.001), had higher body mass index (29 kg/m2 vs. 27 kg/m2, p<0.001), and had higher heart rate (80 bpm vs. 77.5 bpm, p<0.001). Women were more likely to have HFpEF (82% vs. 70.9%, p<0.001), and they differ from men having a higher prevalence of hypertension (78.7% vs. 73.2%, p=0.035) and atrial fibrillation (40.7% vs. 29.9%, p<0.001) but lower prevalence of coronary artery disease (29.5% vs. 54.9%, p<0.001). Women had higher N-terminal pro-B-type natriuretic peptide (691 pg/mL vs. 541 pg/mL, p=0.004), lower hemoglobin (12.7 g/dL vs. 13.8 g/dL, p<0.001), and serum ferritin (51 ng/mL vs. 64 ng/mL, p=0.001) levels, and they had worse diastolic function (E/e'=10 vs. 9, p<0.001). The main cause of heart failure (HF) in women was atrial fibrillation, while it was ischemic heart disease in men.
Conclusion: Clinical characteristics, laboratory findings, and etiological factors are significantly different in female and male patients with HFmrEF and HFpEF. This study offers a broad perspective for increased awareness about this patient profile in Turkey.

3.Is the inferior ST-segment elevation in anterior myocardial infarction reliable in prediction of wrap-around left anterior descending artery occlusion?
Emrah Bozbeyoğlu, Özlem Yıldırımtürk, Emre Aslanger, Barış Şimşek, Can Yucel Karabay, Olcay Özveren, Muzaffer Murat Değertekin
PMID: 31062754  doi: 10.14744/AnatolJCardiol.2019.09465  Pages 253 - 258
Objective: In a subgroup of patients with the anterior wall myocardial infarction (MI), the electrocardiogram (ECG) records a concomitant inferior ST-segment elevation (STE), which is generally explained by a “wrap-around” left anterior descending (LAD) artery occlusion. However, recent evidence indicates that this may be due to a distal LAD occlusion, which may be irrelevant to the LAD length. We investigated the relationship between inferior ST-T changes in anterior MI and the presence of a wrap-around LAD.
Methods: Consecutive patients diagnosed with anterior MI due to an acute LAD occlusion were enrolled into the study. All ECGs were measured manually by a cardiologist, who was blinded to the angiographic outcomes. The site of the LAD occlusion was determined using multiple angiographic views. A wrap-around LAD was defined as a LAD artery from a post-reperfusion coronary angiogram that perfused at least one-fourth of the inferior wall of the left ventricle in the right anterior oblique projection.
Results: A total of 379 anterior MI cases were enrolled, and the final study population consisted of 259 patients. The presence of a wrap-around LAD was more frequent in patients presenting with inferior STE compared with patients without inferior STE (62.1% vs. 30.4%, p=0.001), however, this relationship was weak (φ=0.211). Inferior STE was more frequent in distal occlusions (22.9% vs. 4.3%, p<0.001), which showed a stronger relationship (φ=0.285). The polarity of the T-wave in lead III did not give any clues about the LAD anatomy.
Conclusion: Contrary to the popular acceptance, our results indicate that a wrap-around LAD cannot be reliably diagnosed by ECG.

EDITORIAL COMMENT
4.Left anterior descending artery wrapping around the left ventricular apex predicts additional risk of future events after anterior myocardial infarction
Nobuaki Kobayashi, Akiko Maehara
PMID: 31062762  doi: 10.14744/AnatolJCardiol.2019.79803  Pages 259 - 260
Abstract | Full Text PDF

ORIGINAL INVESTIGATION
5.Treatment with metformin prevents myocardial ischemia-reperfusion injury via STEAP4 signaling pathway
Ting Luo, Xianli Zeng, Wenqi Yang, Yuelan Zhang
PMID: 31062756  doi: 10.14744/AnatolJCardiol.2019.11456  Pages 261 - 271
Objectives: This study aims to investigate the underlying mechanism of metformin in reducing myocardial apoptosis and improving mitochondrial function in rats and H9c2 cells subjected with myocardial ischemia-reperfusion injury (I/R).
Method: Following pretreatment with metformin, male Sprague-Dawley (SD) rats were used to establish an ischemia-reperfusion (I/R) model in vivo. Serum creatinine kinase-MB (CK-MB) and cardiac troponin T (cTnT) levels were examined by ELISA. Infarct size and apoptosis were measured by TTC staining and TUNEL assay. Pathological changes were evaluated by HE staining. H9c2 cells were used to establish a hypoxia-reoxygenation (H/R) model in vitro. Cell apoptosis and mitochondrial membrane potential (MMP) were examined by flow cytometry and Rhodamine 123. The expression levels of STEAP4, Bcl-2, Bax and GAPDH in both myocardial tissues and H9c2 cells were determined by western blotting.
Results: We found that metformin decreased infarct size, increased expression of STEAP4, mitigated myocardial apoptosis and increased mitochondrial membrane potential (MMP) when the models were subjected to H/R or I/R injuries. However, STEAP4 knockdown significantly abrogated the beneficial effect of metformin.
Conclusions: We further demonstrated the protective effect of metformin on cardiomyocytes, which might be at least partly attributable to upregulation of STEAP4. Therefore, STEAP4 might be a new target to decrease apoptosis and rescue mitochondrial function in myocardial ischemia-reperfusion injury.

6.Antithrombotic treatment patterns and stroke prevention in patients with atrial fibrillation in TURKEY: inferences from GARFIELD-AF registry
Begüm Sayın, Sercan Okutucu, Mehmet Birhan Yılmaz, Kurtuluş Özdemir, Ali Aydınlar, Durmuş Yıldıray Şahin, Armağan Altun, Sadık Açıkel, Ertuğrul Okuyan, Murat Sucu, Zeki Öngen, Murat Kazim Ersanlı, Özcan Yılmaz, Mesut Demir, Hasan Pekdemir, Ramazan Topsakal, Mehmet Levent Şahiner, Dursun Aras, Ali Oto
PMID: 31062761  doi: 10.14744/AnatolJCardiol.2019.78178  Pages 272 - 280
The corner stone of atrial fibrillation therapy includes the prevention of stroke with less adverse effects. The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) study provided data to compare treatment strategies in Turkey with other populations and every-day practice of stroke prevention management with complications.Methods: GARFIELD-AF is a large-scale registry that enrolled 52,014 patients in five sequential cohorts at >1,000 centers in 35 countries.This study initiated to track the evolution of global anticoagulation practice, and to study the impact of NOAC therapy in AF. 756 patients from 17 enrolling sites in Turkey were in cohort 4 and 5.Treatment strategies at diagnosis initiated by CHA2DS2-VASc score, baseline characteristics of patients, treatment according to stroke and bleeding risk profiles, INR values were analyzed in cohorts.Also event rates during the first year follow up were evaluated.Results: AF patients in Turkey were mostly seen in young women.Stroke risk according to the CHADS2 score and CHA2DS2-VASc score compared with world data. The mean of risk score values including HAS-BLED score were lower in Turkey than world data.The percentage of patients receiving FXa inhibitor with or without an antiplatelet usage was more than the other drug groups. All-cause mortality was higher in Turkey. Different form world data when HAS-BLED score was above 3, the therapy was mostly changed to antiplatelet drugs in Turkey.Conclusion: The data of GARFIELD-AF provide data from Turkey about therapeutic strategies, best practices also deficiencies in available treatment options, patient care and clinical outcomes of patients with AF.

CONSENSUS REPORT
7.Authorship: From Credit to Accountability Reflections From the Editors´ Network
Fernando Alfonso, Parounak Zelveian, Jean Jacques Monsuez, Michael Aschermann, Michael Boehm, Alfonso Buendia Hernandez, Tzung Dau Wang, Ariel Cohen, Sebija Izetbegovic, Anton Doubell, Dario Echeverri, Nuray Enç, Ignacio Ferreira- González, Anetta Undas, Ulrike Fortmüller, Plamen Gatzov, Carmen Ginghina, Lino Goncalves, Addad Faouzi, Mahmoud Hassanein, Et Al.
PMID: 31062751  doi: 10.14744/AnatolJCardiol.2019.18124  Pages 281 - 286
The Editors´ Network of the European Society of Cardiology (ESC) provides a dynamic forum for editorial discussions and endorses the recommendations of the International Committee of Medical Journal Editors (ICMJE) to improve the scientific quality of biomedical journals. Authorship confers credit and important academic rewards. Recently, however, the ICMJE emphasized that authorship also requires responsibility and accountability. These issues are now covered by the new (fourth) criterion for authorship. Authors should agree to be accountable and ensure that questions regarding the accuracy and integrity of the entire work will be appropriately addressed. This review discusses the implications of this paradigm shift on authorship requirements with the aim of increasing awareness on good scientific and editorial practices.

CASE REPORT
8.Relapsed acute myeloid leukemia presenting with myocardial hypertrophy and constrictive pericardial physiology
Aynur Acibuca, Mahmut Yeral, Nazim Emrah Kocer, Zafer Koc, Hakan Güllü
PMID: 31062759  doi: 10.14744/AnatolJCardiol.2019.64011  Pages 287 - 289
Abstract | Full Text PDF | Video

9.Echocardiographic imaging of systolic anterior motion caused by extremely elongated posterior mitral leaflet in hypertrophic cardiomyopathy
Berhan Keskin, Ali Karagöz, Mahmut Buğrahan Çiçek, Ahmet Karaduman, Gökhan Kahveci
PMID: 31062752  doi: 10.14744/AnatolJCardiol.2019.04741  Pages 289 - 291
Abstract | Full Text PDF | Video

LETTER TO THE EDITOR
10.SUCCESS score for success rate in atrial fibrillation ablation: Does one size fit all?
Mariana Floria, Smaranda Radu, Sînziana Al Shurbaji, Anca Ouatu, Daniela Maria Tanase
PMID: 31062765  doi: 10.14744/AnatolJCardiol.2019.89957  Page 292
Abstract | Full Text PDF

11.Author`s Reply
Fabian Nicolas Jud, Laurent Max Haegeli
PMID: 31062758  Pages 292 - 293
Abstract | Full Text PDF

12.Acute fulminant eosinophilic myocarditis due to Giardia lamblia infection
Joob Beuy, Viroj Wiwanitkit
PMID: 31062753  doi: 10.14744/AnatolJCardiol.2019.07943  Pages 293 - 294
Abstract | Full Text PDF

13.Author`s Reply
Şahin Avşar, Ahmet Öz, Tufan Çınar, Altuğ Ösken, Tolga Sinan Güvenç
PMID: 31062763  Page 294
Abstract | Full Text PDF

E-PAGE ORIGINAL IMAGES
14.Infective endocarditis caused by Alcaligenes faecalis complicated with skin lesions
Ioannis Vogiatzis, Konstantinos Koutsampasopoulos
PMID: 31062755  doi: 10.14744/AnatolJCardiol.2019.10576  Pages E10 - E11
Abstract | Full Text PDF

15.Amiodarone-related blue–gray skin discoloration
Adem Atıcı, Ramazan Asoğlu, Hasan Ali Barman, Irfan Şahin
PMID: 31062764  doi: 10.14744/AnatolJCardiol.2019.84890  Pages E11 - E12
Abstract | Full Text PDF



 
 
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