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Anatol J Cardiol: 20 (6)
Volume: 20  Issue: 6 - December 2018
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EDITORIAL
1.Cardiomyocyte apoptosis, C-reactive protein and more
Çetin Erol
PMID: 30504747  doi: 10.14744/AnatolJCardiol.2018.12  Page 309
Abstract | Full Text PDF

ORIGINAL INVESTIGATION
2.Predictive value of baseline C-reactive protein for periprocedural myocardial infraction of higher risk stratifications: A retrospective cohort clinical study
Mingyang Yao, Linlin Zhao, Lili Wu, Wenbin Zhang, Yi Luan, Jiale Song, Guosheng Fu, Junhui Zhu
PMID: 30297597  doi: 10.14744/AnatolJCardiol.2018.05406  Pages 310 - 317
Objective: It is controversial whether preprocedural elevated high sensitivity C-reactive protein (CRP) could increase the incidence of periprocedural myocardial infraction (PMI) of higher risk stratifications. The primary aim of this study was to evaluate whether preoperative elevated CRP level was related to the incidence of PMI in patients who underwent percutaneous coronary intervention (PCI).
Methods: A total of 4.426 patients [66 y (59, 75); 72.3% males] with normal preprocedural cardiac enzymes were prospectively divided into two groups; the elevated CRP group was defined as CRP >3 mg/L, which was approximately 30.4% of the patients. The relationship between CRP and the incidence of PMI was established by multivariate logistic regression analysis, and multivariate linear regression analysis was used to assess the correlation between CRP and the severity of myocardial injury.
Results: The incidence rates were similar between the two groups with periprocedural myocardial minor necrosis (34.23% versus 32.74%, p=0.607), but significantly differed based on the 2007 (defined as cardiac enzymes >3-fold elevations), 31.25% in high CRP group versus 26.25% in low group [odds ratio (OR) 1.19; p=0.046] and the 2012 universal PMI (defined as cardiac enzymes >5-fold elevations with at least one clinical evidence, such as chest pain, ECG changes or imaging diagnosis of heart ischemia), 19.79% versus 15.35% (OR 1.26, p=0.023); besides, the PMI ratios increased in line with the elevation of CRP (p=0.006 for the 2007 and p=0.011 for the 2012 universal PMI). However, no significant linear relationship was found between CRP and high sensitivity cardiac troponin I peak post-PCI.
Conclusion: Elevated baseline CRP was an independent risk factor for the incidence of the 2007 and the 2012 universal PMI rather than minor necrosis. However, CRP may not correlate with the severity of minor myocardial necrosis in patients with PMI.

3.Effects of transplantation of hypoxia-inducible factor-1α gene-modified cardiac stem cells on cardiac function of heart failure rats after myocardial infarction
Sha Li, Shuren Li
PMID: 30504732  doi: 10.14744/AnatolJCardiol.2018.91979  Pages 318 - 329
Objective: To evaluate the effects of transplantation of hypoxia-inducible factor-1α (HIF-1α) gene-modified cardiac stem cells (CSCs) on the cardiac function of heart failure rats after myocardial infarction (MI).
Methods: Twenty-four Sprague–Dawley rats were randomly divided into three groups: HIF-1α-modified CSCs group, single CSCs group, and model group. The model of heart failure after MI was established by thoracotomy-left anterior descending coronary artery ligation, followed by injection of modified CSCs, single CSCs, and PBS, respectively, 2 weeks later. The results were observed 4 weeks later.
Results: CSCs were infected with recombinant adenovirus. HIF-1α mRNA level of HIF-1α-enhanced green fluorescent protein (EGFP)+CSCs group significantly surpassed those of EGFP+CSCs and CSCs groups (p<0.001). Left ventricular ejection fractions (LVEFs) of HIF-1α+CSCs+MI and CSCs+MI groups significantly increased compared with the model group (p<0.001). The difference between LVEFs before and after transplantation was positively correlated with the survival rate of CSCs in infarction border zone (r=0.867, p<0.001). The apoptosis rate of HIF-1α+CSCs+MI group was significantly lower than that of CSCs+MI group (p=0.008). The expression of vascular endothelial growth factor protein in HIF-1α+CSCs+MI group significantly increased, compared with that of MI group (p<0.001). The capillary density of HIF-1α+CSCs+MI group significantly exceeded that of CSCs+MI group (p<0.001).
Conclusion: Transplantation of either HIF-1α-modified CSCs or single CSCs reduced cardiomyocyte apoptosis in rats with heart failure after MI, promoted vascular regeneration in infarct area, and improved cardiac function. Particularly, HIF-1α-modified CSCs had more significant effects.

4.Transcatheter device closure of atrial septal defects guided completely by transthoracic echocardiography: A single cardiac center experience with 152 cases
Qiang Chen, Hua Cao, Gui-can Zhang, Liang-wan Chen, Heng Lu, Ling-li Yu
PMID: 30504733  doi: 10.14744/AnatolJCardiol.2018.90502  Pages 330 - 335
Objective: This study aimed to assess the safety and feasibility of transcatheter device closure of atrial septal defects (ASDs) guided completely by transthoracic echocardiography (TTE).
Methods: A total of 152 patients underwent transcatheter device closure of ASDs guided completely by TTE in our center from September 2014 to June 2017. We used routine delivery sheaths during the procedure and then closed the ASDs by releasing a domestic occluder.
Results: The closure was successful in 150 patients, and surgical repair was required in two patients. The size of the deployed occluder ranged from 10 mm to 38 mm (21.4±8.5 mm), and the procedure duration ranged from 30 to 90 min (38.2±21.4 min). No fatal complications were observed. Minor complications included transient arrhythmias (n=12) during the process of device deployment. The follow-up period was 3 months to 2 years, with no occluder dislodgment, residual fistula, or thrombus-related complications. In our comparative studies, no statistically significant differences were observed in success rates and complications.
Conclusion: Transcatheter device closure of ASDs guided completely by TTE may be safe and effective and can be an alternative to traditional methods.

5.MicroRNA-21 abrogates palmitate-induced cardiomyocyte apoptosis through caspase-3/NF-κB signal pathways
Xiaodi Zhou, Bo Chang, Yuzhong Gu
PMID: 30504734  doi: 10.14744/AnatolJCardiol.2018.03604  Pages 336 - 346
Objective: The aim of the study was to investigate the role of microRNA-21 (miR-21) in cardiomyocyte apoptosis and to determine a possible mechanism.
Methods: H9c2 embryonic rat heart-derived cells were used in the study. Cell viability was determined using the 3-(4.5-dimethyl-2-thiazolyl)-2,5-diphenyl-2-H-tetrazolium bromide (MTT) assay, and flow cytometry was used to evaluate cell apoptosis. Reverse transcription-polymerase chain reaction and western blot assays were used to detect mRNA and protein expression of the apoptosis-related proteins and miR-21. ELISA was used to detect reactive oxygen species (ROS).
Results: Palmitate exposure greatly reduced miR-21 expression in cardiomyocytes. Apoptosis increased when miR-21 was inhibited with or without palmitate exposure. Consistently, reduced apoptosis was observed when miR-21 was overexpressed in cardiomyocytes. Caspase-3 activity was reduced after palmitate exposure. Bcl-2 protein expression was increased in H9c2 cells when transfected with the miR-21 mimic. MiR-21 overexpression alone did not induce ROS or DNA fragmentation; however, in conjunction with palmitate exposure, miR-21 mimic reduced ROS and DNA fragmentation. Moreover, palmitate administration overcame the antioxidant effect of 3 mM N-acetylcysteine to significantly inhibit apoptosis, DNA fragmentation, and caspase-3 activity. The exposure to palmitate greatly reduced p65 and p-p38 expression in the nucleus. A p38 inhibitor had no effect on the expression of Bcl-2 and cleaved caspase-3 in H9c2 cells alone; however, when combined with exposure to palmitate the p38 inhibitor induced Bcl-2 expression and inhibited caspase-3 activity. The p38 inhibitor by itself did not induce apoptosis, ROS production, or DNA fragmentation in H9c2 cells, but when palmitate was included with the p38 inhibitor, apoptosis, ROS production, and DNA fragmentation were reduced.
Conclusion: miR-21 protects cardiomyocytes from apoptosis that is induced by palmitate through the caspase-3/NF-κB signal pathways.

6.Effect of premature birth on long-term systolic blood pressure variability in women
Linying Shi, Shasha An, Jianqing Niu, Haiyan Zhao, Yangyang Wang, Shouling Wu, Xinchun Yang
PMID: 30504735  doi: 10.14744/AnatolJCardiol.2018.97415  Pages 347 - 353
Objective: To investigate the effect of premature birth (PTB) on long-term systolic blood pressure (SBP) variability (SBPV) in women.
Methods: A total of 1974 pregnant women were divided into PTB group and non-PTB (NPTB) group. The SBP standard deviation (SSD) was calculated by four annual SBP values measured in 2006–2007, 2008–2009, 2010–2011, and 2012–2013. SBP coefficient of variation (SCV) was calculated by dividing SSD with mean SBP. Multivariate logistic regression analysis was used to analyze the influence of PTB on long-time SSD and SCV in women.
Results: SSD and SCV of the PTB group (10.95 mm Hg and 9.05%, respectively) were higher than those of the NPTB group (9.81 mm Hg and 8.23%, respectively), but there were no significant differences (p>0.05). The number of patients with SSD >9.87 mm Hg and SCV >8.28% in the PTB and NPTB groups was 57 (51.40%) and 62 (55.90%) and 747 (40.10%) and 841 (45.10%), respectively. The number of patients with SSD >9.87 mm Hg and SCV >8.28% in the PTB group was significantly higher than that in the NPTB group (p<0.05). Multiple logistic regression analysis showed that after adjusting other risk factors, the PTB group was at a risk of SSD and SCV elevations with OR values of 1.60 (95% CI: 1.06–2.40) and 1.64 (95% CI: 1.10–2.45), respectively.
Conclusion: PTB is a risk factor of long-time SBPV in women, which might be a potential reason for cardiovascular events. Pregnancy may be an important opportunity for early identification of women at an increased risk of cardiovascular disease later in life.

7.Design and rationale for the ASSOS study: Appropriateness of aspirin use in medical outpatients a multicenter and observational study
Oğuzhan Çelik, Cem Çil, Bülent Özlek, Eda Özlek, Volkan Doğan, Özcan Başaran, Erkan Demirci, Lütfü Bekar, Macit Kalçık, Osman Karaarslan, Mücahit Yetim, Tolga Doğan, Vahit Demir, Sedat Kalkan, Buğra Özkan, Şıho Hidayet, Gökay Taylan, Zafer Küçüksu, Yunus Çelik, Süleyman Çağan Efe, Onur Aslan, Murat Biteker
PMID: 30504736  doi: 10.14744/AnatolJCardiol.2018.47587  Pages 354 - 362
Objective: The aim of this study was to describe the current status of aspirin use and the demographic characteristics of patients on aspirin for primary and secondary prevention of cardiovascular diseases.
Methods: The Appropriateness of Aspirin Use in Medical Outpatients: A Multicenter, Observational Study (ASSOS) trial was a multicenter, cross-sectional, and observational study conducted in Turkey. The study was planned to include 5000 patients from 14 cities in Turkey. The data were collected at one visit, and the current clinical practice regarding aspirin use was evaluated (ClinicalTrials.gov number NCT03387384).
Results: The study enrolled all consecutive patients who were admitted to the outpatient cardiology clinics from March 2018 until June 2018. Patients should be at least 18 years old, have signed written informed consent, and on aspirin (80–325 mg) therapy within the last 30 days. Cardiologists from the hospital participates in the study. Patients were divided into 2 categories according to presence or absence of atherosclerotic cardiovascular disease, namely secondary prevention group and primary prevention group, respectively. The appropriate use of aspirin in the primary and secondary prevention groups was assessed according to the European Society of Cardiology guidelines and US Preventive Services Task Force. The patients’ gastrointestinal bleeding risk factors and colorectal cancer risk were evaluated.
Conclusion: The ASSOS registry will be the most comprehensive and largest study in Turkey evaluating the appropriateness of aspirin use. The results of this study help understand the potential misuse of aspirin in a real-world setting.

CASE REPORT
8.Emergent hybrid treatment strategy in a patient with impending rupture of descending aorta aneurysm, including an aberrant right subclavian artery orifice: A rare case report
Habib Çakır, Volkan Çakır, Ismail Yürekli, Utkan Tunca, Yaşar Gökkurt, Köksal Dönmez, Güleycan Erbil, Mert Kestelli, Ali Gürbüz
PMID: 30504737  doi: 10.14744/AnatolJCardiol.2018.00525  Pages 363 - 365
Abstract | Full Text PDF | Video

9.Concomitant left main coronary artery and prosthetic mitral valve thrombosis treatment
Ayhan Olcay
PMID: 30504738  doi: 10.14744/AnatolJCardiol.2018.94220  Pages 365 - 367
Abstract | Full Text PDF

LETTER TO THE EDITOR
10.Caspase recruitment domain-containing protein 8 rs2043211 polymorphism and cardiovascular disease susceptibility
Sora Yasri, Viroj Wiwanitkit
PMID: 30504739  doi: 10.14744/AnatolJCardiol.2018.24892  Page 368
Abstract | Full Text PDF

11.Author`s Reply
Huijuan Huang, Qi Bi, Heng Wei, Beibei Luo, Yan He
PMID: 30504740  Pages 368 - 369
Abstract | Full Text PDF

12.Role of flow preference in decision making regarding the use of Blalock-Taussig shunt
Ece Salihoğlu
PMID: 30504741  doi: 10.14744/AnatolJCardiol.2018.32885  Page 369
Abstract | Full Text PDF

13.Author`s Reply
Ahmet Arnaz, Şenol Pişkin
PMID: 30504742  Page 370
Abstract | Full Text PDF

14.Value of ATRIA risk score and gender in predicting adverse events in patients with myocardial infarction
Can Ramazan Öncel
PMID: 30504743  doi: 10.14744/AnatolJCardiol.2018.25483  Pages 370 - 371
Abstract | Full Text PDF

15.Author`s Reply
Gökhan Çetinkal, Cüneyt Koçaş, Betül Balaban Koçaş, Şükrü Arslan, Okay Abacı, Osman Şükrü Karaca, Yalçın Dalgıç, Özgür Selim Ser, Kudret Keskin, Ahmet Yıldız, Sait Mesut Doğan
PMID: 30504744  Pages 371 - 372
Abstract | Full Text PDF

E-PAGE ORIGINAL IMAGES
16.Percutaneous extraction of an intravascular guidewire retained for 1.5 years
Fatih Öztürk, Adem Atıcı, Ramazan Asoğlu, Hasan Ali Barman, Irfan Şahin
PMID: 30504745  doi: 10.14744/AnatolJCardiol.2018.98150  Page E9
Abstract | Full Text PDF | Video

17.Left ventricular pseudoaneurysm following acute myocardial infarction
Wenjuan Bai, Hong Tang
PMID: 30504746  doi: 10.14744/AnatolJCardiol.2018.39001  Pages E10 - E11
Abstract | Full Text PDF | Video



 
 
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