EDITORIAL | |
1. | Content and news for the Anatolian Journal of Cardiology Bilgin Timuralp PMID: 23211742 doi: 10.5152/akd.2012.251 Page 620 Abstract |Full Text PDF |
ORIGINAL INVESTIGATION | |
2. | Bosentan ameliorates the expression of fibrotic related growth factors and collagen-1 in diabetic mice Bo Yang, Min Li, Zhen-Guo Shi, Quan-Zhou Feng PMID: 22968296 doi: 10.5152/akd.2012.213 Pages 621 - 627 Objective: To investigate the potential beneficial effect of bosentan in ameliorating fibrotic agents in diabetic mice. Methods: Male 6-week old C57BL/6 mice were divided into 3 groups (N=20): Control group, diabetes mellitus (DM) group and DM-B group (diabetes with bosentan group). Streptozotocin (STZ) was injected as 200 mg/Kg for single dose, i.p. (intraperitoneal injection). Fasting blood glucose (FBG) was measured at 0-, 1-, 2-week after STZ injection to confirm that diabetes was induced in the mice. Bosentan (100mg/Kg) and placebo was given i.g. (intragastric administration) once a day immediately after STZ injection for 18 weeks. The mRNA expression of tissue growth factor beta (TGF-b), connective tissue growth factor (CTGF), vascular endothelial growth factor (VEGF) and collagen-1 were evaluated by RT-PCR and real-time PCR. Differences in the data between the groups were compared by Student t-test for independent samples. Results: After 18 weeks of diabetic situation, FBG of DM-B mice was significantly higher than that of control mice and was similar with that of DM mice (DM mice vs. control mice, p<0.001; DM-B vs. control mice, p<0.001; DM mice vs. DM-B mice, p>0.05). The cardiac VEGF mRNA (a potent angiogenic factor) level in DM-B mice was significantly higher than DM mice (p<0.01). The heart of DM-B mice also showed lower expression of fibrotic genes (TGF-b, CTGF and collagen-1) than DM mice (p<0.01). Conclusion: These findings indicate the potential usefulness of an ET receptor antagonist bosentan in the amelioration of fibrotic agents, which may promote tissue fibrosis. This may provide a promising therapeutical strategy for diabetic cardiac fibrosis. |
3. | Clinical biomarkers of high-density lipoprotein dysfunction among middle-aged Turks Altan Onat, Günay Can, Sani Murat, Gökhan Çiçek, Ender Örnek, Hüsniye Yüksel PMID: 22968297 doi: 10.5152/akd.2012.214 Pages 628 - 636 Objective: Impaired function of high-density lipoprotein (HDL) particles generates cardiometabolic disorders in people prone to impaired glucose tolerance for which clinical biomarkers need delineation. Study design: Prospective population-based study. Methods: Totally, data of 2725 adults followed-up over 7.3±3.0 years were analyzed by Cox regression analysis. C-reactive protein (CRP), complement C3 (C3), triglycerides (Trg) and HDL-cholesterol were tested to predict risk for incident diabetes or coronary heart disease (CHD). Results: Beyond atherogenic dyslipidemia, high-Trg/normal HDL-cholesterol category was associated with elevated CRP and diabetes risk in women. Normotriglyceridemic men with normal HDL-cholesterol showed higher apolipoprotein A-I levels and higher diabetes risk than men having low HDL-cholesterol. Diabetes risk doubled in hypertriglyceridemic women regardless of HDL-cholesterol. Trg/HDL-C>2 in men and Trg>1.7 mmol/L in women were best predictors of diabetes. C3>1.3 g/L served additively in women alone. Regarding CHD risk, not CRP, but C3 contributed independently to Trg/HDL>2 in men [RR 2.46 (95% CI 1.33; 4.53)]; a high ratio was merely additive to elevated CRP in women. Among five cut-off values, predictive values for diabetes were highest for CRP >2.5 mg/L in men, Trg>1.7 mmol/L and C3>1.3 g/dL in women. Conclusion: Trg/HDL-C ratio >2 and/or CRP >2.5 mg/L in men and Trg>1.7 mmol/L+C3>1.3 g/dL in women are most appropriate markers regarding impaired antiinflammatory or atheroprotective HDL function. In normotriglyceridemic men with normal HDL-cholesterol levels, diabetes risk may be elevated due to presumably dysfunctional apolipoprotein A-I. |
4. | Coronary artery ectasia is associated with atrial electrical and mechanical dysfunction: an observational study Serkan Öztürk, Mehmet Özyaşar, Selim Suzi Ayhan, Mehmet Fatih Özlü, Alim Erdem, Aytekin Alçelik, Selçuk Öztürk, Kemalettin Erdem, Mehmet Yazıcı PMID: 22968298 doi: 10.5152/akd.2012.215 Pages 637 - 643 Objective: The aim of our study was to investigate total atrial conduction time and left atrial (LA) mechanical function in patients with isolated coronary artery ectasia (ICAE). Methods: Sixty patients with ICAE without any visible coronary stenosis were enrolled to this cross-sectional observational study. The control group consisted of 40 age- and gender-matched patients. Left atrial mechanical functions were measured by the method of discs in the apical-four chamber echocardiographic view. LA mechanical function parameters were calculated. P wave dispersion was measured on electrocardiography (ECG). The total atrial conduction time (PA-tissue Doppler imaging (TDI) duration) was assessed by measuring the time interval between the beginning of the P wave on the surface ECG and point of the peak A wave on TDI from LA lateral wall just over the mitral annulus. Student t, Mann-Whitney U, Pearson’s, and Spearman’s correlation analysis and multiple regression analysis were used for statistical analysis. Results: The clinical and laboratory characteristics were similar in two groups. Both groups were similar in terms of Vmax and LA total emptying volume (29.0±7.3 vs. 31.9±6.5 mL/m2, p=0.082 and 19.9±5.1 vs. 20.0±5.2 mL/m2, p=0.821). However, LA passive emptying volume and LA passive emptying fraction were significantly decreased with ICAE patients (11.1±3.2 vs. 13.5±3.8 ml/m2, p=0.005 and 35.2±7.2 vs. 47.8±9.4 mL/m2, p<0.001). But LA active emptying volume and LA active emptying fraction were significantly increased in ICAE patients (9.1±2.6 vs. 6.4±3.0 mL/m2, p<0.001 and 45.3±8.1 vs. 40.7±6.7 mL/m2, p=0.002). PA-TDI duration was measured significantly higher in patients with ICAE than control group (131.8±5.7 vs. 114.4±9.1 ms, p<0.001). Multiple linear regression analyses showed that ectatic segment number was an independent factor of PA-TDI duration (β=0.581, 95% CI=4.046-6.295, p<0.001). Conclusion: Our study demonstrated presence of LA electrical and mechanical dysfunction in patients with ICAE. LA dysfunction may be associated with cardiac pathologies as arrhythmias, decrease in cardiac output and congestive failure. |
EDITORIAL COMMENT | |
5. | Coronary artery ectasia and atrial electrical and mechanical dysfunction Usama Boles PMID: 23018088 doi: 10.5152/akd.2012.243 Pages 644 - 645 Abstract |Full Text PDF |
ORIGINAL INVESTIGATION | |
6. | Prevalence and clinical features of atrial fibrillation in diabetic neuropathy: a cross-sectional, observational study İdil Gökçen Koçağra Yağız, Serdar Bayata, Murat Yeşil, Tülay Kurt İncesu, Erdinç Arıkan, Nursen Postacı PMID: 22968299 doi: 10.5152/akd.2012.216 Pages 646 - 651 Objective: This cross-sectional, observational study investigated prevalence and clinical features of atrial fibrillation (AF) in diabetic patient groups with or without autonomic neuropathy. Methods: One hundred and fourteen consecutive patients with pharmacologically treated type-II diabetes mellitus were enrolled for this study in our institution between January 2010 and December 2010. All patients underwent 12-lead electrocardiography on the day of enrollment for AF detection. All diabetic patients underwent neurologic examination for the presence of diabetic autonomic neuropathy (DAN). Following clinical evaluation, sympathetic skin responses (SSR) and RR interval variability (RRIV) analysis were used for the detection of autonomic neurologic involvement. Patients were divided into two groups according to presence (Group 1) or absence (Group 2) of DAN. Patient groups with or without DAN were compared for AF occurrence. Continuous and categorical data were compared with independent samples t- test and Chi-square statistical tests respectively. Results: Atrial fibrillation prevalence was 24% (n=29) in study population. Diabetic autonomic neuropathy was diagnosed in 47 (39%) patients. Basal characteristics of patients with or without DAN were comparable except glycosylated hemoglobin A (HbA1c) levels. HbA1c levels were found significantly higher in patients with DAN. Atrial fibrillation was diagnosed in 14 patients in Group 1 and in 15 patients in Group 2. Significantly increased AF prevalence (31.9% vs. 20.8%, p=0.014, in groups with and without DAN respectively) was observed in patient group with diabetic autonomic neuropathy. Conclusion: The results of this study demonstrated an increased prevalence of AF in patients with diabetic autonomic neuropathy compared with non-neuropathic, diabetic patients. Further investigation of this relation with prospective studies is needed to demonstrate a causal relationship between diabetic autonomic neuropathy and AF. |
7. | Increased gamma-glutamyl transferase level is associated with absence of coronary collateral vessels in patients with acute coronary syndrome: an observational study Mustafa Duran, Özgür Günebakmaz, Onur Kadir Uysal, Ahmet Çelik, Mikail Yarlioglues, Ekrem Karakaya PMID: 22968300 doi: 10.5152/akd.2012.217 Pages 652 - 658 Objective: Elevated serum gamma-glutamyl transferase (GGT) level has been proposed as a risk factor for coronary artery disease and is associated with poor clinical outcome in acute coronary syndrome (ACS). We aimed to evaluate the relationship between GGT level and presence of coronary collateral vessels (CCV) patients with ACS. Methods: We evaluated 178 patients with ACS in this cross-sectional-observational study. Traditional laboratory and clinical parameters and serum GGT levels were measured. All patients underwent coronary angiography on the first day after admission and patients who had >80% stenosis of coronary artery were included in the study. The CCVs graded according to the Rentrop scoring system and Rentrop 0, 1, 2 and 3 were determined in respectively 76 (42.7%), 32 (18.0%), 33 (18.5%), and 37 (20.8%) patients. Rentrop grade 0 was accepted as no CCV development (Group 1), Rentrop grades 1-2-3 were accepted as presence of CCV development (Group 2). Statistical analysis was performed using independent-samples t, Mann-Whitney U and Chi-squared tests, logistic regression and receiver operator curve analyses. Results: Mean age was 62±10 years and 134 (75.3%) of patients were male. Group 1 consisted of 76 (42.7%) patients and Group 2 consisted of 102 (57.3%) patients. The median and minimum-maximum values of serum GGT were 33.5 (8-128) U/L for Group 1 and 23 (2-83) U/L for Group 2. Absence of CCV was significantly associated with high levels of GGT (p<0.001), alanine-aminotransferase (p=0.001), glucose (p=0.011) and low levels of total protein (p=0.020). At multivariate analysis, high levels of GGT were independent predictors of absence of CCV (OR=0.953, 95%CI 0.912-0.996, p=0.031). Conclusion: High levels of GGT on admission were associated with absence of CCV in patients with ACS. |
8. | Relationship between cardiac troponin-T and right ventricular Tei index in patients with hemodynamically stable pulmonary embolism: an observational study Savaş Özsu, Abdülkadir Kırış, Yılmaz Bülbül, Funda Öztuna, Kayıhan Karaman, Merih Kutlu, Tevfik Özlü PMID: 22968301 doi: 10.5152/akd.2012.218 Pages 659 - 665 Objective: The role of increased troponin level in risk stratification of acute pulmonary embolism (PE) is well documented. However, relation between right ventricular (RV) myocardial performance (Tei) index and cardiac troponin-T (cTn-T) has not been well investigated. The purpose of this observational prospective study was to assess the relationship between the RV Tei index and cTn-T in patients with acute normotensive PE. Methods: Thirty-eight patients with acute PE diagnosed by computed spiral tomography pulmonary angiography were enrolled to this prospective observational study. All study population underwent a comprehensive echocardiographic study including tissue Doppler imaging within first 12 hours of admission. cTn-T levels were measured on admission. Follow-up echocardiography was performed routinely at the 7th day of hospitalization. Echocardiographic evaluation was repeated at 90 days in patients with insufficient improvement of RV Tei index. The difference between the baseline and follow-up data was analyzed using the paired sample t-test or Wilcoxon test according to normality of distribution. Results: The mean of the RV Tei index was 0.46±0.14 and the mean systolic pulmonary artery pressure (sPAP) was 40±20 mmHg. Increased cTn-T level was detected in 37% of the patients (normal value 0.01< ng/mL). Significant correlations were observed between RV Tei index and sPAP with cTn-T levels (r=0.467 and r=0.468, p<0.001, respectively). In logistic regression analysis, RV Tei index was associated with positive cTn-T values (OR-136, 95% CI: 1.3-14657, p=0.039). After the anticoagulant treatment, RV Tei index and sPAP were significantly improved. Conclusion: RV Tei index is frequently impaired in patients with acute PE and a significant recovery is seen after the treatment. Therefore, RV Tei index may be used both the diagnosis of RV dysfunction and the assessment of treatment effectiveness. RV Tei index is may predict myocardial injury in PE. |
EDITORIAL COMMENT | |
9. | Right ventricular functions in pulmonary embolism Sait Demirkol, Şevket Balta PMID: 23018089 doi: 10.5152/akd.2012.244 Pages 666 - 667 Abstract |Full Text PDF |
ORIGINAL INVESTIGATION | |
10. | Cardiac responses to long duration and high magnitude +Gz exposure in pilots: An observational study Cengiz Öztürk, M. Savaş İlbasmış, Ahmet Akın PMID: 22968302 doi: 10.5152/akd.2012.219 Pages 668 - 674 Objective: In military aviation, high performance aircraft pilots are exposed to +Gz acceleration at longer durations and higher magnitude than transport/helicopter pilots. The purpose of this study was to reveal the negative or positive cardiac responses to this occupational high +Gz exposure. Methods: Our study design was cross-sectional and observational. We have evaluated 21 echocardiographic parameters of 63 pilots who applied for aircrew periodic medical examination. Of 63 pilots, 33 were grouped as high performance aircraft pilots group (Group A) and 30 were grouped as control group (Group B) whose aircraft type was transport or helicopter. Means of demographic and echocardiography parameters between two groups were compared statistically with Student's t-test, Mann- Whitney U or Chi-square test as appropriate. Results: Among all echocardiographic parameters, mean TV A (tricuspid valve peak velocity during late diastolic filling) was significantly higher and TV E (peak velocity during early diastolic filling)/ A ratio was significantly lower for Group A pilots (p<0.05). In Group A pilots, mean TV A and TV E/A ratio were (52.12±13.85) and (1.36±0.30) respectively. In Group B pilots, mean TV A and TV E/A ratio were (42.61±6.42) and (1.53±0.20) respectively (p=0.001 for TVA and p=0.005 for TV E/A). Mean pulmonary artery pressure (PAP) of Group A pilots (32.04±9.09) was higher than Group B pilots (28.76±7.9) but it was not statistically significant (p>0.05). Conclusion: We conclude that according to the results of our study, long term +Gz exposure has no effects on cardiac morphologic and systolic functions but has effects on right ventricular diastolic functions. We have considered that these effects may be a result of chronic +Gz adaptation or high PAP levels. |
EDITORIAL COMMENT | |
11. | Long-term high +Gz effects on cardiac functions in the pilots Mehmet Gül, Musa Salmanoğlu PMID: 23018090 doi: 10.5152/akd.2012.245 Page 675 Abstract |Full Text PDF |
REVIEW | |
12. | Drug eluting stents: Current status and new developments Gökhan Ertaş, Heleen Van Beusekom PMID: 22989796 doi: 10.5152/akd.2012.220 Pages 676 - 683 Despite the favorable impact of drug eluting stents on stent restenosis, their long-term reliability is considered worrisome by some because of stent thrombosis. Often attributed to adverse reactions to the stent platform, both the drugs and polymer characteristics have been further advanced with current technologies. The present review discussed current drug eluting stents and new developments. |
13. | Brain derived neurotrophic factor (BDNF) in cardiometabolic physiology and diseases İlker Taşçı, Hasan Kutsi Kabul, Aydoğan Aydoğdu PMID: 22989797 doi: 10.5152/akd.2012.221 Pages 684 - 688 Important advances in our understanding of the relationships between adipose tissue derived peptides, namely adipokines, and their effects on cardiovascular functions have been achieved in recent years. Growing knowledge of adipokine biology is revealing the complexity of these proteins. Adipose tissue releases some other proteins called neurotrophins that are mainly active in central and peripheral nervous system. However, secretion and activity of these hormones are not only limited to neuronal cells and tissues, but they also take part in adipose tissue development, energy metabolism, glucose utilization, insulin sensitivity, inflammation, lipoprotein synthesis, and atherosclerosis. In this review, we describe the most recent advances in the functions of brain derived nerve growth factor (BDNF), a major type of neurotrophins, focusing primarily on cardiovascular and metabolic diseases. |
CASE REPORT | |
14. | Management of acute ischemic stroke occurred during thrombolytic treatment of a patient with prosthetic mitral valve thrombosis: Continuing thrombolysis on top of thrombolysis Mehmet Özkan, Ozan M. Gürsoy, Banu Atasoy, Zülal Uslu PMID: 22989798 doi: 10.5152/akd.2012.222 Pages 689 - 690 Abstract |Full Text PDF |
15. | Starr-Edwards caged ball valve pursuing to astonish us-38 years in mitral position Gökhan Gökaslan, Neyyir Tuncay Eren PMID: 22989799 doi: 10.5152/akd.2012.223 Pages 690 - 691 Abstract |Full Text PDF |
16. | Treatment of aortic valve stenosis and gastrointestinal bleeding by transcatheter aortic valve implantation in Heyde syndrome Mehmet Gül, Özgür Sürgit, Ender Özal, Aslı Örmeci, İhsan Bakır PMID: 22989800 doi: 10.5152/akd.2012.224 Pages 691 - 693 Abstract |Full Text PDF |
17. | Double covered stent closure of extracardiac Fontan multiple fenestrations Arda Saygılı, Kürşad Tokel, Özgen Ilgan Koçyiğit, Tayyar Sarıoğlu PMID: 22989801 doi: 10.5152/akd.2012.225 Pages 693 - 695 Abstract |Full Text PDF |
18. | Acute aortic dissection in a 10-year-old boy with bicuspid aortic valve Burak Onan, Alper Güzeltaş, Ender Ödemiş, İhsan Bakır PMID: 22989802 doi: 10.5152/akd.2012.226 Pages 695 - 696 Abstract |Full Text PDF |
DIAGNOSTIC PUZZLE | |
19. | Multiple fatal images in right heart Müslim Şahin, Elnur Alizade, Cemile Pirmemmedova, Göksel Acar PMID: 23018092 doi: 10.5152/akd.2012.247 Page 697 Abstract |Full Text PDF |
LETTER TO THE EDITOR | |
20. | Unconscious plagiarism and withdrawal of the manuscript under consideration F. Suna Kıraç PMID: 22989803 doi: 10.5152/akd.2012.227 Page 698 Abstract |Full Text PDF |
21. | Giant J-wave (Osborn wave) related to hypothermia and hypokalemia Murat Yalçın, Zafer Işılak, Ömer Uz, Mehmet Doğan PMID: 22989805 doi: 10.5152/akd.2012.229 Pages 699 - 700 Abstract |Full Text PDF |
22. | Increased level of cardiac troponin-I due to rheumatoid factor positivity in a healthy patient with normal coronary arteries Ahmet Çağrı Aykan, Can Yücel Karabay, Mubariz Rasulzada PMID: 22989806 doi: 10.5152/akd.2012.230 Pages 700 - 701 Abstract |Full Text PDF |
23. | Multilateral coronary fistulas terminating in the lung parenchyma Zeki Doğan, Ahmet Karabulut PMID: 22989807 doi: 10.5152/akd.2012.231 Pages 701 - 702 Abstract |Full Text PDF |
24. | Minimally invasive on-pump aortic valve replacement with thoracic epidural anesthesia Fikret Maltepe, Kıvanç Sadık Metin, Baran Şevket Uğurlu, Öztekin Oto PMID: 22989808 doi: 10.5152/akd.2012.232 Page 702 Abstract |Full Text PDF |
25. | Knowledge and adherence to treatment in patients with poor or improved anticoagulation control Meral Altıok, Funda Kuyurtar, Fatma Babalıklı, Semra Erdoğan PMID: 22989809 doi: 10.5152/akd.2012.233 Page 703 Abstract |Full Text PDF |
DIAGNOSTIC PUZZLE | |
26. | Multiple fatal images in right heart Müslim Şahin, Elnur Alizade, Cemile Pirmemmedova, Göksel Acar PMID: 23018092 Page 704 Abstract |Full Text PDF |
MISCELLANEOUS | |
27. | Prof. Dr. Naci Bor - a man chasing curiosity Gülsen Öner PMID: 23018091 doi: 10.5152/akd.2012.246 Pages 705 - 708 Abstract |Full Text PDF |
28. | Statement on matching language to the type of evidence used in describing outcomes data PMID: 23211743 doi: 10.5152/akd.2012.252 Page 709 Abstract |Full Text PDF |
AUTHOR INDEX | |
29. | Author Index Pages 710 - 715 Abstract |Full Text PDF |
SUBJECT INDEX | |
30. | Subject Index Pages 716 - 723 Abstract |Full Text PDF |
REFEREE INDEX | |
31. | Referee Index Pages 724 - 725 Abstract |Full Text PDF |
E-PAGE ORIGINAL IMAGES | |
32. | Mitral regurgitation secondary to mitral anterior leaflet rupture after mitral valvuloplasty Sait Demirkol, Murat Ünlü, Şevket Balta, Atila İyisoy PMID: 22989810 doi: 10.5152/akd.2012.234 Page E40 Abstract |Full Text PDF |
33. | Incidental diagnosis of an aneurysm of the mitral valve posterior leaflet Turgay Işık, Mustafa Kurt, Erkan Ayhan, İbrahim Halil Tanboğa PMID: 22989811 doi: 10.5152/akd.2012.235 Pages E40 - E41 Abstract |Full Text PDF |
34. | Incidentally diagnosed pseudoaneurysm of mitral-aortic intervalvular fibrosa Mehmet Doğan, Mustafa Gökhan Vural, Aysel Türkvatan, Ekrem Yeter PMID: 22989812 doi: 10.5152/akd.2012.236 Pages E41 - E42 Abstract |Full Text PDF |
35. | 3D echocardiographic evaluation of ruptured pseudoaneurysm of the mitral-aortic intervalvular fibrosa Barış Güngör, Servet Altay, Şennur Ünal Dayı, Osman Bolca PMID: 22989813 doi: 10.5152/akd.2012.237 Pages E42 - E43 Abstract |Full Text PDF |
36. | Cor triatriatum sinister demonstrated by 3D-transesophageal echocardiography Özcan Başaran, Ahmet Güler, Can Yücel Karabay, Elif Eroğlu PMID: 22989814 doi: 10.5152/akd.2012.238 Pages E43 - E44 Abstract |Full Text PDF |
37. | Incidentally diagnosed unusual large epicardial adipose tissue Ferhat Özyurtlu, Erkan Ayhan, Turgay Işık, Halit Acet PMID: 22989815 doi: 10.5152/akd.2012.239 Page E44 Abstract |Full Text PDF |
38. | Very late diagnosed complication of coronary artery bypass surgery: coronary artery to right ventricular fistula Serkan Duyuler, Pınar Türker Bayır, Burcu Demirkan, Sadık Kadri Açıkgöz PMID: 22989816 doi: 10.5152/akd.2012.240 Pages E44 - E45 Abstract |Full Text PDF |
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