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The relationship between gamma-glutamyltransferase and coronary collateral circulation in patients with chronic total occlusion [Anatol J Cardiol]
Anatol J Cardiol. 2014; 14(1): 48-54 | DOI: 10.5152/akd.2013.236  

The relationship between gamma-glutamyltransferase and coronary collateral circulation in patients with chronic total occlusion

Müslüm Şahin1, Serdar Demir1, Mehmet Emin Kalkan2, Birol Özkan3, Gökhan Alıcı4, Kamil Cantürk Çakalağaoğlu3, Mehmet Vefik Yazıcıoğlu5, Sabit Sarıkaya6, Murat Biteker7, Mehmet Muhsin Türkmen4
1Clinic of Cardiology, Kartal Koşuyolu Yüksek İhtisas Education and Training Hospital, İstanbul-Turkey
2Clinic of Cardiology, Kartal Koşuyolu Heart and Research Hospital; İstanbul-Turkey
3Clinics of Cardiology Cardiac Surgery, Kartal Koşuyolu Heart Education and Research Hospital; İstanbul-Turkey
4Clinic of Cardiology, Kartal Koşuyolu Heart Education and Research Hospital, İstanbul-Turkey
5Clinic of Cardiology, Kartal Koşuyolu Heart Education and Training Hospital, İstanbul-Turkey
6Süreyyapaşa Göğüs Kalp ve Damar Hastalıkları Eğitim Hastanesi Kalp ve Damar Cerrahisi Kliniği
7Clinic of Cardiology, Haydarpaşa Numune Hospital, İstanbul-Turkey
8Clinic of Cardiology, Kartal Koşuyolu Heart Education and Research Hospital, İstanbul-Turkey

Objective: The aim of this study was to evaluate the relation between blood gamma-glutamyltransferase (GGT) levels and coronary collateral circulation in patients with chronic total occlusion (CTO). Methods: Two hundred twenty-two patients with chronic stable coronary artery disease (CAD) and CTO were included in this cross-sectional, observational study. Coronary collaterals were graded from 0 to 3 according to the Rentrop method. Patients with grade 0-1 collateral development were regarded as poor collateral group (n=66) while patients with grade 2-3 collateral development were regarded as good collateral group (n=156). Statistical analysis was performed using independent samples t, Mann-Whitney U and Chi-square tests, logistic regression and receiver operator curve analysis. Results: The poor coronary collateral group had significantly higher levels of serum GGT compared to the good collateral group (p<0.001). Multiple logistic regression analysis showed that GGT levels were independent predictors of poor collateral circulation (OR-0.946, 95% CI=0.918-0.9719, p<0.001). The result of ROC curve analysis for GGT was as following: area under the ROC curve (AUC)=0.732, 95% CI: 0.622-0.841, p<0.001. Conclusion: Higher GGT levels are associated with poor coronary collateral circulation in patients with CTO. GGT may be used to predict the grade of coronary collateral circulation in CTO patients with chronic stable CAD.

Keywords: coronary artery disease, collateral circulation, oxidative stress, gamma-glutamyl transferase, regression analysis, diagnostic accuracy


Müslüm Şahin, Serdar Demir, Mehmet Emin Kalkan, Birol Özkan, Gökhan Alıcı, Kamil Cantürk Çakalağaoğlu, Mehmet Vefik Yazıcıoğlu, Sabit Sarıkaya, Murat Biteker, Mehmet Muhsin Türkmen. The relationship between gamma-glutamyltransferase and coronary collateral circulation in patients with chronic total occlusion. Anatol J Cardiol. 2014; 14(1): 48-54


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