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Usefulness of surface electrocardiogram in predicting the clinical course of patients with hypertrophic cardiomyopathy [Anatol J Cardiol]
Anatol J Cardiol. 2007; 7(Suppl 1): 178-181

Usefulness of surface electrocardiogram in predicting the clinical course of patients with hypertrophic cardiomyopathy

Fatih Bayrak1, Gökhan Kahveci2, Bülent Mutlu3, Muzaffer Değertekin4, Ertan Demirtaş5
1Department of Cardiology, Faculty of Medicine, Yeditepe University, İstanbul
2Department of Cardiology, Rize State Hospital, Rize
3Marmara Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, İstanbul, Türkiye
4Department of Cardiology, Yeditepe University Hospital, İstanbul, Turkey
5Department of Cardiology, Yeditepe University Hospital, Kozyatağı İstanbul,Turkey

Objective: Few data exist regarding the prognostic value of QT dispersion in hypertrophic cardiomyopathy (HCM). In this study, we prospectively investigated the association between baseline QT dispersion and clinical course of HCM. Methods: Overall, 101 patients with asymmetric septal hypertrophy (59 men, mean age 45±16 years, range 13-74 years) were included in the study and were followed up for 595±367 days for clinical endpoints defined as cardiac death and hospitalization due to worsening in heart failure symptoms. QRS duration, QT interval, and JT interval were manually measured on 12-lead electrocardiogram (ECG). QT dispersion and corrected QT dispersion were calculated accordingly. The ECG findings of the patients with and without clinical endpoints were compared. Results: Twenty-nine patients experienced clinical endpoints (3 sudden deaths, 26 hospitalizations due to worsening heart failure). The measurements of QT, JT and QRS intervals were all comparable between the two groups (p>0.05 for all). QT dispersion and corrected QT dispersion were significantly different between patients with and without clinical endpoints (64±30 ms vs. 83±18 ms and 71±33 ms vs. 90±18 ms, respectively, p=0.001 for both). Corrected QT dispersion >80 ms detected patients with clinical endpoints with sensitivity and specificity of 79% and 75%, respectively. Patients with corrected QT dispersion <80 ms were significantly free of clinical endpoints. Conclusion: In conclusion, for patients with hypertrophic cardiomyopathy, measurement of baseline corrected QT dispersion from surface ECG may be used to identify those at risk for clinical deterioration at long-term follow-up.

Keywords: Hypertrophic cardiomyopathy, QT dispersion, prognosis


Fatih Bayrak, Gökhan Kahveci, Bülent Mutlu, Muzaffer Değertekin, Ertan Demirtaş. Usefulness of surface electrocardiogram in predicting the clinical course of patients with hypertrophic cardiomyopathy. Anatol J Cardiol. 2007; 7(Suppl 1): 178-181


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