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Evaluation of the Tp-Te interval, Tp-Te/QTc ratio, and QT dispersion in patients with Turner syndrome [Anatol J Cardiol]
Anatol J Cardiol. 2018; 20(2): 93-99 | DOI: 10.14744/AnatolJCardiol.2018.98250  

Evaluation of the Tp-Te interval, Tp-Te/QTc ratio, and QT dispersion in patients with Turner syndrome

Adem Atıcı1, Cafer Panç2, Ekrem Bilal Karaayvaz3, Ahmet Demirkıran4, Orkide Kutlu5, Kamber Kaşalı6, Elmas Kekeç7, Lütfullah Sarı7, Zeynep Nur Akyol Sarı7, Ahmet Kaya Bilge8
1Department of Cardiology, Muş State Hospital; Muş-Turkey
2Department of Cardiology, Mehmet Akif Ersoy Training and Research Hospital; İstanbul-Turkey
3Department of Cardiology, Bağcılar Training and Research Hospital; İstanbul-Turkey
4Department of Cardiology, VU University Medical Center; Amsterdam-The Netherlands
5Department of Internal Medicine, Okmeydanı Training and Research Hospital; İstanbul-Turkey
6Department of Biostatistics, Atatürk University; Erzurum-Turkey
7İstanbul University İstanbul Faculty of Medicine; İstanbul-Turkey
8Department of Cardiology, İstanbul University İstanbul Faculty of Medicine; İstanbul-Turkey

Objective: To evaluate ventricular repolarization parameters using the interval from the peak to the end of the T wave (Tp–Te), together with QT and corrected QT (QTc) intervals, QT dispersion (QTd), and Tp-Te/QTc ratio in patients with Turner syndrome (pwTS) and to compare the results with those from healthy controls.
Methods: In total, 38 patients previously diagnosed with Turner syndrome (TS) and 35 healthy girls (controls) were included in our cross-sectional study. Twelve-lead electrocardiography (ECG) and echocardiography after a 30-min rest were performed. The QT, QTc, QTd, Tp-Te interval, and Tp-Te/QTc ratio were determined.
Results: No differences in age or sex were observed between the groups. QT intervals were similar in both groups [pwTS: 354.76±25.33 ms, controls (C): 353.29±17.51 ms, p=0.775]. pwTS had significantly longer QTc and QTd than controls (411.87±22.66 ms vs. 392.06±13.21 ms, p<0.001 and 40.31±2.02 ms vs. 37.54±1.83 ms, p<0.001, respectively). Similarly, the Tp-Te interval and Tp-Te/QTc ratio were significantly longer in pwTS than in controls (71.89±3.39 ms vs. 65.34±2.88 ms, p<0.001 and 0.17±0.01 vs. 0.16±0.01, p=0.01).
Conclusion: As pwTS have longer QTc, QTd, Tp–Te interval, and Tp-Te/QTc ratio, an annual follow-up with ECG can provide awareness and even prevent sudden death in them. Also avoiding the use of drugs that makes repolarization anomaly and having knowledge about the side effects of these drugs are essential in pwTS.

Keywords: Turner syndrome, sudden cardiac death, QTc, QTd, Tp-Te, Tp-Te/QTc


Adem Atıcı, Cafer Panç, Ekrem Bilal Karaayvaz, Ahmet Demirkıran, Orkide Kutlu, Kamber Kaşalı, Elmas Kekeç, Lütfullah Sarı, Zeynep Nur Akyol Sarı, Ahmet Kaya Bilge. Evaluation of the Tp-Te interval, Tp-Te/QTc ratio, and QT dispersion in patients with Turner syndrome. Anatol J Cardiol. 2018; 20(2): 93-99

Corresponding Author: Ekrem Bilal Karaayvaz, Türkiye


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