ISSN 2149-2263 | E-ISSN 2149-2271 Home      
 
Volume : 22 Issue : 3
Current Issue Archive Popular Article Ahead of Print

   
Quick Search





 
Effects of balanced propofol sedation on QT, corrected QT, and P-wave dispersion on upper endoscopy [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(5): 328-332 | DOI: 10.5152/AnatolJCardiol.2015.6264  

Effects of balanced propofol sedation on QT, corrected QT, and P-wave dispersion on upper endoscopy

Esef Bolat1, Mehmet Çelikbilek2, Savaş Sarıkaya3, Yunus Keser Yılmaz4, Serkan Doğan5, Ömer Özbakır5
1Departments Of Anesthesiology, Faculty Of Medicine, Bozok University; Yozgat- Turkey
2Gastroenterology, Faculty Of Medicine, Bozok University; Yozgat- Turkey
3Cardiology, Faculty Of Medicine, Bozok University; Yozgat- Turkey
4Cardiovascular Surgery, Faculty Of Medicine, Bozok University; Yozgat- Turkey
5Department Of Gastroenterology, Faculty Of Medicine, Erciyes University; Kayseri- Turkey

Objective: Combined sedation with propofol and benzodiazepines, known as balanced propofol sedation (BPS), was developed to increase patient comfort during endoscopy. However, the effects of BPS on P-wave dispersion (Pwd), QT interval, and corrected QT (QTc) interval after endoscopy have not been investigated.
Methods: The study population consisted of 40 patients with BPS and 42 without sedation who were scheduled to undergo upper endoscopy in this cross-sectional prospective study. Patients with hypertension, diabetes mellitus, renal failure, chronic obstructive pulmonary disease, coronary artery disease, or valvular heart disease and those on medications that interfere with cardiac conduction times were excluded. Electrocardiograms (ECGs) was recorded in all patients pre-endoscopy and 10 min post-endoscopy. QT, QT dispersion (QTd), and Pwd were defined from 12-lead ECG. The QTc interval was calculated using Bazett’s formula. All analyses were performed using SPSS 15.0.
Results: Post-endoscopy P max duration and Pwd were prolonged compared with baseline values (86±13 ms vs. 92±10 ms and 29±12 ms vs. 33±12 ms, respectively; p<0.05). Post-endoscopy QTc and QTd were decreased compared with baseline values, but these decreases were not statistically significant (431±25 ms vs. 416±30 ms and 62±28 ms vs. 43±22 ms, respectively; p>0.05).
Conclusion: The present study showed that P-wave duration and Pwd values increased after endoscopy with a combination of midazolam and propofol sedation. Physicians should be made aware of the potential effects of BPS in terms on P-wave duration and Pwd values. (Anatol J Cardiol 2016; 16: 328-32)

Keywords: propofol, midazolam, electrocardiography, P-wave dispersion, QT interval, corrected QT


Esef Bolat, Mehmet Çelikbilek, Savaş Sarıkaya, Yunus Keser Yılmaz, Serkan Doğan, Ömer Özbakır. Effects of balanced propofol sedation on QT, corrected QT, and P-wave dispersion on upper endoscopy. Anatol J Cardiol. 2016; 16(5): 328-332

Corresponding Author: Mehmet Çelikbilek, Türkiye


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar




 
 
KARE Publishing | Copyright © 2018 Turkish Society of Cardiology