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The Effect of Glutamate and Aspartate on Myocardial Protection at Cardiopulmonary Bypass [Anatol J Cardiol]
Anatol J Cardiol. 2004; 4(2): 114-119

The Effect of Glutamate and Aspartate on Myocardial Protection at Cardiopulmonary Bypass

Ali Vefa Özcan1, Yavuz Beşoğul2, Bülent Tünerir2, Saadettin Dernek2, Tuncay Erden2, Coşkun Özdemir2, Orçun Ünal2, Recep Aslan2, Tuğrul Kural3
1Department of Cardiovascular Surgery Faculty of Medicine, Pamukkale University Denizli, Turkey
2Osmangazi Üniversitesi Tıp Fakültesi Göğüs Kalp Damar Cerrahisi Anabilim Dalı, Eskişehir
3Department of Cardiovascular Surgery Eskisehir Osmangazi University, Medical Faculty, Eskişehir

Objective: To determine whether glutamat and aspartat enriched cold crystalloid cardioplegia which was given in antegrade way has any effect on the myocardial protection during cardiopulmonary bypass. Material and Methods: Thirty-four patients who were electively undergone open heart surgery at Osmangazi University Faculty of Medicine, thoracic and cardiovascular surgery department, between March 2001 and May 2001 were included in this study. The patients were divided in two groups, each consisting of 17 patients. In group 1 coronary artery bypass surgery (CABG) was performed in 11 patients, mitral valve replacement (MVR) in 3 patients, aortic valve replacement (AVR) in 1 patient and AVR and MVR in 2 patients. While in group 2 CABG was performed in 13 patients and MVR was done in 4 patients. Group 1 patients received antegrade glutamat and aspartat (15 mmol/L) enriched cold crystalloid cardioplegia and group 2 patients were given cold crystalloid cardioplegia by antegrade route. Age, gender, diabetes mellitus, hypertension, preoperative myocardial infarction, smoking, ejection fraction, aortic cross-clamp time, need to defibrillation, inotropic support, and intraaortic balloon pump were recorded. The levels of cardiac troponin I (cTI) and creatine kinase myocardial band fraction (CK-MB) were measured in arterial blood samples at five different times. Statistical analysis was performed using Student’s t-test and Chi-square test. Results: There were no statistically significant differences in cTI and CK-MB values in blood samples taken at 5 different times pre and postoperatively between group 1 and group 2. Conclusion: It is concluded that glutamat and aspartat enriched cold crystalloid cardioplegia does not have any effect on myocardial protection.

Keywords: Glutamate, aspartate, cardiopulmonary bypass, myocardial protection


Kardiyopulmoner Baypasta Glutamat ve Aspartatın Miyokardiyal Koruma Üzerine Etkisi

Ali Vefa Özcan1, Yavuz Beşoğul2, Bülent Tünerir2, Saadettin Dernek2, Tuncay Erden2, Coşkun Özdemir2, Orçun Ünal2, Recep Aslan2, Tuğrul Kural3
1Department of Cardiovascular Surgery Faculty of Medicine, Pamukkale University Denizli, Turkey
2Osmangazi Üniversitesi Tıp Fakültesi Göğüs Kalp Damar Cerrahisi Anabilim Dalı, Eskişehir
3Department of Cardiovascular Surgery Eskisehir Osmangazi University, Medical Faculty, Eskişehir

Anahtar Kelimeler: Glutamat, aspartat, kardiyopulmoner baypas, miyokardiyal koruma


Ali Vefa Özcan, Yavuz Beşoğul, Bülent Tünerir, Saadettin Dernek, Tuncay Erden, Coşkun Özdemir, Orçun Ünal, Recep Aslan, Tuğrul Kural. The Effect of Glutamate and Aspartate on Myocardial Protection at Cardiopulmonary Bypass. Anatol J Cardiol. 2004; 4(2): 114-119


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