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Is there any relationship between coronary artery disease and postprandial triglyceride levels? [Anatol J Cardiol]
Anatol J Cardiol. 2011; 11(3): 201-206 | DOI: 10.5152/akd.2011.053  

Is there any relationship between coronary artery disease and postprandial triglyceride levels?

İnci Aslı Atar1, İlyas Atar2, Alp Aydınalp2, Çağatay Ertan2, Hüseyin Bozbaş2, Bülent Özin2, Aylin Yıldırır2, Haldun Müderrisoğlu2
1Cardiology Clinic, Güven Hospital, Ankara
2Department of Cardiology, Faculty of Medicine, Başkent University, Ankara, Turkey

Objective: We aimed to evaluate the relationship between postprandial triglyceride (PPTG) levels and coronary artery disease (CAD). Methods: A total of 80 patients were included in this prospective cohort study. Oral lipid loading was used in order to measure PPTG levels. In the fasting state and after the high fat breakfast, triglyceride levels were measured by enzymatic methods at 2nd, 4th, 6th and 8th hours. We made subgroup analysis to show the effects of lipid loading on triglyceride levels in patients with and without fasting hypertriglyceridemia. We evaluated triglyceride levels and changes of triglyceride levels in percentages after lipid loading using a general linear model for repeated measures. Sample size analysis was performed. Results: Baseline clinical, demographic and laboratory characteristics of both groups were similar. The peak triglyceride levels were seen at the 4th hour in both groups. Triglyceride levels were significantly increased after lipid-rich-breakfast loading compared to baseline levels in both groups (p<0.001) but these changes were not significant (p=0.279). In patients with elevated fasting triglyceride levels, the area under the plasma triglyceride concentration curve was significantly larger in CAD group than control group (334±103 vs. 233±58 mg/dl, p=0.02). Conclusion: Our data show that in patients who have a high fasting triglyceride level, high levels of PPTG may be related to CAD, however high PPTG levels are not related to CAD in patients with normal fasting levels of triglyceride.

Keywords: Coronary artery disease, postprandial triglyceride, lipid loading, hypertriglyceridemia


İnci Aslı Atar, İlyas Atar, Alp Aydınalp, Çağatay Ertan, Hüseyin Bozbaş, Bülent Özin, Aylin Yıldırır, Haldun Müderrisoğlu. Is there any relationship between coronary artery disease and postprandial triglyceride levels?. Anatol J Cardiol. 2011; 11(3): 201-206


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