ISSN 2149-2263 | E-ISSN 2149-2271 Home      
 
Volume : 23 Issue : 1
Current Issue Archive Popular Article Ahead of Print

   
Quick Search





 
The etiopathogenesis of pulmonary hypertension: inflammation, vascular remodeling [Anatol J Cardiol]
Anatol J Cardiol. 2010; 10(Suppl 1): 5-8 | DOI: 10.5152/akd.2010.113  

The etiopathogenesis of pulmonary hypertension: inflammation, vascular remodeling

Meral Kayıkçıoğlu1
Ege Üniversitesi Tıp Fakültesi Kardiyoloji Anabilim Dalı, İzmir

Pulmonary arterial hypertension (PAH) is a progressive disease marked by increased pulmonary artery resistance leading to right heart failure with a high mortality. PAH is histologically characterized by endothelial and smooth muscle cell proliferation, medial hypertrophy, inflammation, and thrombosis in situ. Elevated pulmonary vascular resistance is the result of an imbalance between locally produced vasodilators and vasoconstrictors, in addition to vascular wall remodeling. Recent evidence demonstrates that inflammatory processes are involved in the generation of pulmonary vascular remodeling leading to PAH. Viral infections or similar immune-modulators trigger auto-antibody generation by endothelial injury and indirectly lead to PAH. All these immune-modulators associated with PAH, are also known to decrease the regulatory subgroups (CD4) of T cells. With a recognition of important role of inflammation in the development of PAH, anti-inflammatory agents and anti-cancer drugs are accepted as potential specific targets for PAH treatment. Though clinical studies are not enough, anti-inflammatory agents seem to be promising in the treatment of this devastating disease.

Keywords: Pulmonary hypertension, inflammation, vascular remodeling


Meral Kayıkçıoğlu. The etiopathogenesis of pulmonary hypertension: inflammation, vascular remodeling. Anatol J Cardiol. 2010; 10(Suppl 1): 5-8


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share


Similar articles
PubMed
Google Scholar




 
 
KARE Publishing | Copyright © 2018 Turkish Society of Cardiology