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Serum uric acid level is an independent risk factor for presence of calcium in coronary arteries: an observational case-controlled study [Anatol J Cardiol]
Anatol J Cardiol. 2013; 13(2): 139-145 | DOI: 10.5152/akd.2013.039  

Serum uric acid level is an independent risk factor for presence of calcium in coronary arteries: an observational case-controlled study

Aslı İnci Atar1, Ömer Çağlar Yılmaz1, Kayıhan Akın2, Yusuf Selçoki3, Okan Er3, Beyhan Eryonucu3
1Department of Cardiology Faculty of Medicine, Fatih University, Ankara-Turkey
2Department of Radiology, Faculty of Medicine, Fatih University, Ankara-Turkey
3Department of Cardiology Faculty of Medicine, Fatih University, Ankara-Turkey
4Department of Cardiology Faculty of Medicine, Fatih University, Ankara-Turkey
5Department of Cardiology Faculty of Medicine, Fatih University, Ankara-Turkey

 

Objective: A link between uric acid levels and cardiovascular diseases has been previously reported. Coronary artery calcium score (CACS) is a marker of atherosclerotic disease and a predictor of cardiovascular events. We sought to determine if serum uric acid level is an independent risk factor for the presence of calcium in coronary arteries.

Methods: Four hundred and forty-two patients who were evaluated in the cardiology outpatient clinic for suspected coronary heart disease with a low-moderate risk for coronary artery disease were included in this observational case-controlled study. Serum uric acid levels were measured with colorimetric methods. CACS were performed using a 64-slice CT scanner. Patients were divided to 3 groups according to their CACS value (Group 1: CACS=0, Group 2: CACS 1-100, Group 3: CACS>100).

Results: The demographical characteristics and laboratory findings of 3 groups were similar, except age, fasting glucose levels and serum uric acid levels. Serum uric acid levels were found to increase significantly with increasing CACS (p=0.001). Patients were grouped according to presence CAC (CACS=0 and CACS?1) and in the multiple regression analysis, age (OR, 1.11, 95% CI, 1.07-1.16), smoking (OR, 3.83, 95% CI, 2.06-7.09), serum uric acid levels (OR, 1.26, 95% CI, 1.04-1.54) and average 10-year total risk of Framingham risk score (OR, 1.13, 95% CI, 1.04-1.09) appeared as independent factors predictive of presence of CAC (p<0.05).

Conclusion: Serum uric acid level is an independent risk factor for presence of coronary calcium. Moreover, increasing levels of serum uric acid are associated with increasing CACS. 

Keywords: Uric acid, coronary artery calcium score, coronary heart disease, logistic regression analysis


Aslı İnci Atar, Ömer Çağlar Yılmaz, Kayıhan Akın, Yusuf Selçoki, Okan Er, Beyhan Eryonucu. Serum uric acid level is an independent risk factor for presence of calcium in coronary arteries: an observational case-controlled study. Anatol J Cardiol. 2013; 13(2): 139-145


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