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Arterial distensibility in Wegener’s granulomatosis: a carotid - femoral pulse wave velocity study [Anatol J Cardiol]
Anatol J Cardiol. 2007; 7(3): 281-285

Arterial distensibility in Wegener’s granulomatosis: a carotid - femoral pulse wave velocity study

Mustafa Yıldız1, Mehmet Soy2, Turhan Kürüm3, Banu Şahin Yıldız4
1Kartal Koşuyolu Heart Education and Research Hospital, Cardiology, Istanbul, Turkey
2Department of Rheumatology/Internal Medicine School of Medicine, Trakya University, Edirne
3Department of Cardiology, School of Medicine, Trakya University, Edirne
4Department of Internal Medicine, Dr Lütfi Kırdar Kartal Educational and Research Hospital, İstanbul

Objective: The purpose of this study was to test the hypothesis; that chronic inflammation may impair vascular function and lead to an increase of arterial pulse wave velocity (PWV) in patients with Wegener’s granulomatosis (WG). Methods: We recruited 5 patients with WG and 5 healthy age and sex matched controls in this cross-sectional case-controlled study. Aortic PWV was determined by using an automatic device (Complior Colson, France), which allowed on-line pulse wave recording and automatic calculation of PWV. Results: The carotid-femoral (aortic) PWV was increased in patients with WG as compared with control group (p=0.04). Although we found positive correlation between PWV and heart rate (r=0.75, p=0.01), we did not find any significant correlation between PWV and anthropometric and other hemodynamic parameters (p>0.05). In addition, we found positive correlation between PWV and erythrocyte sedimentation rate in patients with WG (r=0.90, p=0.03). Conclusion: Pulse wave velocity is increased and arterial distensibility decreased in patients with WG. Measurements of carotid-femoral (aortic) PWV may provide an easy and noninvasive technique to identify patients at increased risk of arterial disease.

Keywords: Pulse wave velocity, arterial distensibility, Wegener’s granulomatosis, inflammation


Wegener granülomatozu’nda karotis-femoral nab›z dalga hızı ile belirlenen arteryel geniflleyebilirlik

Mustafa Yıldız1, Mehmet Soy2, Turhan Kürüm3, Banu Şahin Yıldız4
1Kartal Koşuyolu Heart Education and Research Hospital, Cardiology, Istanbul, Turkey
2Department of Rheumatology/Internal Medicine School of Medicine, Trakya University, Edirne
3Department of Cardiology, School of Medicine, Trakya University, Edirne
4Department of Internal Medicine, Dr Lütfi Kırdar Kartal Educational and Research Hospital, İstanbul

Anahtar Kelimeler: Nabız dalga hızı, arteryel distansibilite, Wegener granülomatozu, enflamasyon


Mustafa Yıldız, Mehmet Soy, Turhan Kürüm, Banu Şahin Yıldız. Arterial distensibility in Wegener’s granulomatosis: a carotid - femoral pulse wave velocity study. Anatol J Cardiol. 2007; 7(3): 281-285


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