ISSN 2149-2263 | E-ISSN 2149-2271
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Serum neutrophil gelatinase-associated lipocalin levels are correlated with the complexity and the severity of atherosclerosis in acute coronary syndrome [Anatol J Cardiol]
Anatol J Cardiol. 2015; 15(6): 450-455 | DOI: 10.5152/akd.2014.5513

Serum neutrophil gelatinase-associated lipocalin levels are correlated with the complexity and the severity of atherosclerosis in acute coronary syndrome

Korhan Soylu1, Gökhan Aksan2, Gökay Nar3, Metin Özdemir4, Okan Gülel1, Sinan İnci3, Aytekin Aksakal5, Ayşegül İdil Soylu6, Özcan Yılmaz1
1Department of Cardiology, Faculty of Medicine, Ondokuz Mayıs University; Samsun-Turkey
2Department of Cardiology, Gazi State Hospital; Samsun-Turkey
3Department of Cardiology, Aksaray State Hospital; Aksaray-Turkey
4Department of Microbiology, Gazi State Hospital; Samsun-Turkey
5Department of Cardiology, Samsun Training and Research Hospital; Samsun-Turkey
6Department of Radiology, Samsun Training and Research Hospital; Samsun-Turkey

Objective: Neutrophil gelatinase-associated lipocalin (NGAL) is a novel inflammatory marker that is released from neutrophils. In this study, we evaluated the correlation between serum NGAL level and clinical and angiographic risk scores in patients diagnosed with non-ST elevation acute coronary syndrome (NSTE-ACS).
 
Methods: Forty-seven random NSTE-ACS patients and 45 patients with normal coronary arteries (NCA) who underwent coronary angiography were enrolled in the study. GRACE risk score and SYNTAX and Gensini risk scores were used, respectively, for the purpose of clinical risk assessment and angiographic risk scoring. Serum NGAL level was measured via ELISA in peripheral blood samples obtained from the patients at the time of admission.
 
Results: Serum NGAL level was significantly higher in the NSTE-ACS group compared to the control group (112.3±49.6 ng/mL vs. 58.1±24.3 ng/mL, p<0.001). There was a significant positive correlation between serum NGAL levels and the GRACE (r=0.533 and p<0.001), SYNTAX (r=0.395 and p=0.006), and Gensini risk scores (r=0.575 and p<0.001). The intermediate-high SYNTAX (>22) group had statistically significantly higher serum NGAL levels compared to the low SYNTAX (?22) group (143±29.5 ng/mL vs. 98.7±43.2 ng/mL, p=0.001).

 
Conclusion: NGAL level was positively correlated with lesion complexity and severity of coronary artery disease in patients with NSTE-ACS. Serum NGAL levels on admission are associated with increased burden of atherosclerosis in patients with NSTE-ACS.
 

Keywords: neutrophil gelatinase-associated lipocalin, non-ST elevation acute coronary syndrome, GRACE, SYNTAX, Gensini

Akut koroner sendromda aterosklerozun şiddeti ve kompleksitesinin serum neutrophil gelatinase-associated lipokalin seviyesi ile ilişkisi

Korhan Soylu1, Gökhan Aksan2, Gökay Nar3, Metin Özdemir4, Okan Gülel1, Sinan İnci3, Aytekin Aksakal5, Ayşegül İdil Soylu6, Özcan Yılmaz1
1Department of Cardiology, Faculty of Medicine, Ondokuz Mayıs University; Samsun-Turkey
2Department of Cardiology, Gazi State Hospital; Samsun-Turkey
3Department of Cardiology, Aksaray State Hospital; Aksaray-Turkey
4Department of Microbiology, Gazi State Hospital; Samsun-Turkey
5Department of Cardiology, Samsun Training and Research Hospital; Samsun-Turkey
6Department of Radiology, Samsun Training and Research Hospital; Samsun-Turkey

Amaç: Neutrophil gelatinase-associated lipocalin (NGAL) nötrofillerden salınan yeni bir enflamatuvar belirteçtir. Bu çalışmada ST elevasyonsuz akut koroner sendromlu (NSTE-ACS) hastalardaki klinik ve anjiyografik risk skorları ile NGAL seviyesi arasındaki ilişki araştırılmıştır.
 
Yöntemler: Çalışmaya koroner anjiyografi uygulanan 47 NSTE-ACS hastası ile stabil angina nedeniyle koroner anjiyografi yapılan ve koroner arterleri normal saptanan 45 kontrol hastası dahil edildi. Klinik risk değerlendirmesi amacıyla GRACE risk skoru, anjiyografik risk değerlendirmesi amacıyla da SYNTAX ve Gensini risk skorları kullanıldı. Başvuru esnasında hastalardan alınan kan örneklerinden ELİSA yöntemi ile serum NGAL düzeyi hesaplandı.
 
Bulgular: Serum NGAL seviyesi NSTE-ACS grubunda kontrol grubuna göre anlamlı olarak daha yüksekti (112,3±49,6 ng/mL’ye karşın 58,1±24,3 ng/mL, p<0,001). Serum NGAL düzeyleri ile GRACE risk skoru (r=0,533 ve p<0,001), SYNTAX (r=0,395 ve p=0,006) ve GENSİNİ risk skorları (r=0,575 ve p<0,001) arasında anlamlı pozitif korelasyon vardı. NGAL seviyesi orta-yüksek SYNTAX (>22) grupta düşük SYNTAX (?22) gruba göre anlamlı şekilde yüksekti (143±29,5 ng/mL’ye karşın 98,7±43,2 ng/mL, p=0,001).
 
Sonuç: Çalışmamızda NGAL seviyesi NSTE-ACS hastalarındaki lezyon kompleksitesi ve koroner arter hastalığının yaygınlığı ile pozitif korelasyon göstermiştir. Başvuru sırasındaki serum NGAL seviyesi NSTE-ACS hastalarındaki artmış aterosklerotik yük ile ilişkilidir.

 


Anahtar Kelimeler: neutrophil gelatinase-associated lipocalin, ST elevasyonsuz akut koroner sendrom, GRACE, SYNTAX, Gensini.

Korhan Soylu, Gökhan Aksan, Gökay Nar, Metin Özdemir, Okan Gülel, Sinan İnci, Aytekin Aksakal, Ayşegül İdil Soylu, Özcan Yılmaz. Serum neutrophil gelatinase-associated lipocalin levels are correlated with the complexity and the severity of atherosclerosis in acute coronary syndrome. Anatol J Cardiol. 2015; 15(6): 450-455
Manuscript Language: English


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