ISSN 2149-2263 | E-ISSN 2149-2271
pdf
The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation [Anatol J Cardiol]
Anatol J Cardiol. 2010; 10(3): 209-215 | DOI: 10.5152/akd.2010.059

The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation

Volkan Bozdemir1, Önder Kırımlı2, Bahri Akdeniz3, Ayfer Ülgenalp4, Abdurrahman Aslan1, Veli Kala1, Erdem Özel1
1Department of Cardiology Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey
2Department of Cardiology, School of Medicine, Dokuz Eylül University, İzmir, Turkey
3Department of Cardiology School of Medicine, Dokuz Eylül University, İzmir, Turkey
4Department of Medical Genetics, Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey
5Department of Cardiology Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey
6Department of Cardiology Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey
7Department of Cardiology Faculty of Medicine, Dokuz Eylül University, İzmir, Turkey

Objective: The role of coagulation parameters left atrial thrombus formation in atrial fibrillation has not been investigated before. We aimed to investigate the association between the beta-fibrinogen gene polymorphism or glycoprotein IIIa gene polymorphism and presence of left atrial (LA) thrombus or spontaneous echo contrast (SEC) in patients with atrial fibrillation (AF). Methods: Forty-seven patients with AF, in whom transesophageal echocardiography was performed, were included to this cross-sectional observational study. Patients were divided in two groups; those with LA thrombus (n=24) were assigned to group 1 and those without thrombus-in group 2 (n=23). DNA analysis was conducted to determine gene polymorphism in all patients. Mann-Whitney U test or Chi-square tests were used for statistical analysis Results: There were no significant differences between groups regarding to demographic and clinical characteristics. The frequency of beta-fibrinogen 455 G/A polymorphism was higher (37.5%) in group 1 as compared to group 2 (15.1%) but it did not reach statistical difference (p=0.23). When we added patients with severe SEC in the study group (patients with severe SEC and/or thrombus n=27) the difference (44.40%-10%) reached the statistical difference (p=0.01). Glycoprotein IIIa Pl A1/A2 polymorphism was not different between groups with (p=0.82) or without SEC (p=0.73). Conclusion: In patients with atrial fibrillation, beta-fibrinogen 455 G/A gene polymorphism is associated with the presence of left atrial thrombus and severe SEC. Beta-fibrinogen 455 G/A gene polymorphism may be a promising marker for the prediction of thromboembolism risk in patients with atrial fibrillation.

Keywords: Atrial fibrillation, thrombus, left atrium, gene polymorphism, beta-fibrinogen, glycoprotein IIIa

Volkan Bozdemir, Önder Kırımlı, Bahri Akdeniz, Ayfer Ülgenalp, Abdurrahman Aslan, Veli Kala, Erdem Özel. The association of beta-fibrinogen 455 G/A gene polymorphism with left atrial thrombus and severe spontaneous echo contrast in atrial fibrillation. Anatol J Cardiol. 2010; 10(3): 209-215
Manuscript Language: English


Journal Metrics

Journal Citation Indicator: 0.18
CiteScore: 1.1
Source Normalized Impact
per Paper:
0.22
SCImago Journal Rank: 0.348

Quick Search



Copyright © 2024 The Anatolian Journal of Cardiology



Kare Publishing is a subsidiary of Kare Media.