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Femoral neck and spine bone mineral density-Surrogate marker of aortic calcification in postmenopausal women [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(3): 202-209 | DOI: 10.5152/akd.2015.6016  

Femoral neck and spine bone mineral density-Surrogate marker of aortic calcification in postmenopausal women

Petar Avramovski1, Maja Avramovska2, Miroslav Lazarevski3, Aleksandar Sikole4
1Department Of Internal Medicine, Jzu Clinical Hospital “d-r Trifun Panovski”; Bitola- Republic Of Macedonia
2University Clinic Of Obstetrics And Gynecology, Medical Faculty “ss. Cyril And Methodius University”; Skopje- Republic Of Macedonia
3Department Of Internal Medicine, Jzu City General Hospital “8 Th September”; Skopje- Republic Of Macedonia
4University Clinic Of Nephrology, Medical Faculty “ss. Cyril And Methodius University”; Skopje- Republic Of Macedonia

Objective: Osteoporosis and abdominal aortic calcification (AAC) are associated with increased morbidity and mortality in postmenopausal women. The aim of this study was to determine the accuracy of anterior-posterior (AP) dual-energy X-ray absorptiometry (DXA) compared with that of X-ray lateral lumbar radiography (LLR) in detecting and scoring AAC.
Methods: In this cross-sectional study conducted in 56 postmenopausal asymptomatic females aged 59.0±9.3 years and who never used medications to treat osteoporosis before, we determined femoral neck and lumbar spine bone mineral density (BMD) by AP DXA and AAC by X-ray LLR. We hypothesized that the subtracted femoral neck BMD (BMDFN) from lumbar spine BMD (BMDLS) presented as ΔBMD=BMDLSBMDFN would have a diagnostic value in detecting abdominal vascular calcification.
Results: The mean BMDFN was 0.744±0.184 g/cm2, and the mean BMDLS was 0.833±0.157 g/cm2 (p<0.0001); the mean ΔBMD was 0.089±0.077 g/ cm2, and the mean AAC score was 2.182±1.982. Bivariate Pearson’s correlation analysis revealed a significant positive correlation between AAC and ΔBMD (r=0.449, p=0.0006); by linear regression analysis, R2=0.2019, and by multiple regression analysis, βst=13.5244 (p<0.0001). We found a sensitivity of 64.3% and specificity of 82.9% by receiver operating characteristic [ROC; area under the ROC curve (AUC=0.759)] in the prediction of AAC by ΔBMD.
Conclusion: This AP subtracting BMD DXA method provides a useful tool for detecting and scoring subclinical and extensive AAC in postmenopausal women using a simple, semiquantitative, and accurate scoring system with minimal radiation exposure and low cost. (Anatol J Cardiol 2016; 16: 202-9)

Keywords: aortic diseases, vascular calcification, osteoporosis, postmenopausal, absorptiometry DXA scan, femur neck, lumbar vertebrae


Petar Avramovski, Maja Avramovska, Miroslav Lazarevski, Aleksandar Sikole. Femoral neck and spine bone mineral density-Surrogate marker of aortic calcification in postmenopausal women. Anatol J Cardiol. 2016; 16(3): 202-209

Corresponding Author: Petar Avramovski, Macedonia


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