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Failing heart; remodel, replace or repair? [Anatol J Cardiol]
Anatol J Cardiol. 2008; 8(Suppl. 2): 148-157

Failing heart; remodel, replace or repair?

Ahmet Rüçhan Akar1, Serkan Durdu1, Günseli Çubukçuoğlu Deniz2, Alp Aslan3, Kamil Can Akçalı4, Ümit Özyurda5
1Department of Cardiovascular Surgery, Heart Center, Ankara University School of Medicine, Ankara; Ankara University Biotechnology Institute, Ankara
2Ankara University Biotechnology Institute, Ankara
3Division of Cardiovascular Surgery, Umut Hospital, Ankara
4Department of Molecular Biology and Genetics, Bilkent University, Ankara, Turkey
5Department of Cardiovascular Surgery, Heart Center, Ankara University School of Medicine, Ankara

In the era of proton-antiproton collisions, stem cell field has emerged as the newly recognized protons of regenerative medicine. Great interest and enthusiasm were depending on their behavioral difference such as self-renewal, clonogenicity and differentiation into functional progeny that may become vehicles for regenerative medicine. Although progress has evolved dramatically strategies using stem-cell-driven cardiac regeneration involve extremely complex and dynamic molecular mechanisms. Cell death in transplanted heart continues to be a significant issue. Every step from stem cell homing, and migration to retention, engraftment, survival and differentiation in cardiac cytotherapy deserves intense research for optimum results. Furthermore, regeneration of contractile tissue remains controversial for human studies and careful interpretation is warranted for modest benefit in clinical trials. Currently, the only realistic approach to replace the damaged cardiomyocytes is cardiac transplantation for patients with end-stage heart failure. Ultimately, the giant footsteps in cell-based cardiac repair can only be achieved by an enthusiastic but also skeptical teams adhering to good manufacturing practices. Better understanding of cell-fate decisions and functional properties in cardiac cytotherapy may change the erosion of initial enthusiasm and may open new prospects for cardiovascular medicine.

Keywords: stem cell, cardiac regeneration, cell-based therapy, angiogenesis, bone marrow cells, plasticity


Ahmet Rüçhan Akar, Serkan Durdu, Günseli Çubukçuoğlu Deniz, Alp Aslan, Kamil Can Akçalı, Ümit Özyurda. Failing heart; remodel, replace or repair?. Anatol J Cardiol. 2008; 8(Suppl. 2): 148-157

Corresponding Author: Ahmet Rüçhan Akar, Türkiye


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