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The association between serum angiogenin and osteopontin levels and coronary collateral circulation in patients with chronic total occlusion [Anatol J Cardiol]
Anatol J Cardiol. 2019; 22(2): 77-84 | DOI: 10.14744/AnatolJCardiol.2019.88555  

The association between serum angiogenin and osteopontin levels and coronary collateral circulation in patients with chronic total occlusion

Kadri Murat Gürses1, Muhammed Ulvi Yalçın2, Duygu Koçyiğit3, Muhammed Said Beşler4, Hande Canpınar5, Banu Evranos4, Hikmet Yorgun4, Mehmet Levent Şahiner4, Ergün Barış Kaya4, Necla Özer4, Dicle Güç5, Kudret Aytemir4, Lale Tokgözoğlu4
1Department of Basic Medical Sciences, Faculty of Medicine, Adnan Menderes University; Aydın-Turkey
2Department of Cardiology, Faculty of Medicine, Selçuk University; Konya-Turkey
3Cardiology Clinics, Afyonkarahisar Dinar State Hospital; Afyonkarahisar-Turkey
4Department of Cardiology, Hacettepe University Faculty of Medicine, Ankara-Turkey.
5Department of Basic Oncology, Cancer Institute, Hacettepe University Faculty of Medicine, Ankara-Turkey

Objective: A well-developed coronary collateral circulation lowers both in-hospital and long-term morbidity and mortality limiting the infarct. Angiogenin (AGN) and osteopontin (OPN) are known to be potent inducers of angiogenesis. The aim of the present study was to investigate the relationship between serum ANG and OPN levels and collateral filling grade in subjects with stable coronary artery disease (SCAD).
Methods: A total of 122 age- and gender-matched consecutive patients who were found to have total occlusion (n=70) and no significant stenosis in epicardial coronary arteries (n=52) who underwent coronary angiography due to SCAD between January 2015 and July 2017 were included in the study. AGN and OPN levels were measured using enzyme linked immunosorbent assay. Coronary collateral circulation was graded using Rentrop’s classification of collateral filling.
Results: A total of 52 patients (61.60±11.78 years, 61.5% male) without significant epicardial coronary artery stenosis and 70 patients (62.87±8.24 years, 65.7% male) with totally occluded coronary arteries were included in the study. Subjects with total occlusion had significantly higher levels of AGN [122.00 (79.00–623.00) pg/mL vs. 98.00 (18.00–160.00) pg/mL, p<0.001] and OPN [1863.50 (125.00–6500.00) pg/mL vs. 451.00 (112.00– 1850.00) pg/mL, p<0.001] than those without significant stenosis. In addition, AGN [127.00 (87.00–623.00) pg/mL vs. 110.00 (79.00–188.00) pg/mL, p=0.011] and OPN [2681.00 (126.00–6500.00) pg/mL vs. 649.00 (125.00–4255.00) pg/mL, p=0.001] levels were significantly higher in patients with better developed collaterals. Serum AGN and OPN levels were found to be significantly associated with coronary collateral development.
Conclusion: AGN and OPN are associated with better developed coronary collateral circulation and may have therapeutic implications for the promotion of coronary collateral development.

Keywords: coronary collateral circulation, osteopontin, angiogenin


Kadri Murat Gürses, Muhammed Ulvi Yalçın, Duygu Koçyiğit, Muhammed Said Beşler, Hande Canpınar, Banu Evranos, Hikmet Yorgun, Mehmet Levent Şahiner, Ergün Barış Kaya, Necla Özer, Dicle Güç, Kudret Aytemir, Lale Tokgözoğlu. The association between serum angiogenin and osteopontin levels and coronary collateral circulation in patients with chronic total occlusion. Anatol J Cardiol. 2019; 22(2): 77-84

Corresponding Author: Muhammed Ulvi Yalçın, Türkiye


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