ISSN 2149-2263 | E-ISSN 2149-2271 Home      
Volume : 24 Issue : 2
Current Issue Archive Popular Article Ahead of Print

Statins in stroke prevention [Anatol J Cardiol]
Anatol J Cardiol. 2008; 8(3): 217-222

Statins in stroke prevention

Ömer Gedikli, Merih Baykan
Karadeniz Teknik Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Trabzon, Türkiye

Cholesterol lowering with statins has been proven to reduce vascular events in primary and secondary prevention of coronary artery disease (CAD). Epidemiologic studies found no or little association between blood cholesterol levels and stroke. However, randomized trials in patients with CAD have shown that statins decrease stroke incidence. These statin trials indicate 21% relative risk reductions for stroke. In subgroup analysis of the Heart Protection Study, simvastatin had no effect on stroke recurrence, in patients with a previous stroke. Recently, Stroke Prevention by Aggressive Reduction in Cholesterol Levels study showed that treatment with high dose atorvastatin reduced risk of stroke in patients with recent stroke and transient ischemic attack and no known CAD. In this review, we will discuss the effects of statins on stroke and the potential mechanisms of action.

Keywords: Stroke, statin

Ömer Gedikli, Merih Baykan. Statins in stroke prevention. Anatol J Cardiol. 2008; 8(3): 217-222

Corresponding Author: Ömer Gedikli, Türkiye

Full Text PDF
Download citation
Reference Manager
Share with email
Send email to author

Similar articles
Google Scholar

KARE Publishing | Copyright © 2019 Turkish Society of Cardiology