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Serum Levels of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 in Acute Coronary Syndromes and Relationship with Prognosis [Anatol J Cardiol]
Anatol J Cardiol. 2004; 4(3): 209-212

Serum Levels of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 in Acute Coronary Syndromes and Relationship with Prognosis

Cevad Şekuri1, Ece Onur2, Ozan Ütük3, Özgür Bayturan1, Özlem Arslan4, Uğur Kemal Tezcan5
1Özel Kent Hastanesi, Kardiyoloji Kliniği, İzmir
2Celal Bayar Üniversitesi Tıp Fakültesi,Biyokimya Anabilim Dalı, Manisa
3Department of Cardiology, School of Medicine, Celal Bayar University, Manisa, Turkey
4Department of Cardiology, Özel Doğuş Hospital, Mersin
5Celal Bayar Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Manisa

Objective: The aim of the present study was to examine the levels of insulin-like growth factor (IGF-I) and binding protein-3 (IGFBP-3) in acute coronary syndrome (ACS) and their relationship with prognosis. Methods: Thirty patients with ACS (22 male, 8 female) were included in our study. Patient’s population included 20 patients with ST elevation myocardial infarction (STEMI) and 10 with non-ST-elevation ACS. Death, re-infarction, revascularization and malignant arrhythmia were monitored during 3 months. Study group was compared with 20 healthy subjects (Controls). Blood samples were collected in the first 24 hours and at the end of third month. Serum IGF-I and IGFBP-3 levels were determined by radioimmunoassay method. Results: We found decreased level of IGF-I only in the STEMI group (105±84 ng/ml vs. 715±150 ng/ml, p<0.0001). There were no significant differences in IGFBP-3 levels between two groups. Serum IGF-I levels were significantly increased after 3rd month in the STEMI group (356±72 ng/ml vs. 105±84 ng/ml, p=0.025). There was no relationship between IGF-I, IGFBP-3 levels and cardiovascular events occurred during 90 days of follow-up. Conclusion: These data allows to suggest that significantly decreased level of IGF-I in STEMI group of ACSs can be used as a marker of myocardial necrosis. There was no relationship between IGF-I level and cardiovascular events occurred in 90 days, so this parameter can not be used as a negative prognostic factor.

Keywords: Acute coronary syndrome, insulin-like growth factor, IGF-finding protein-3


Akut Koroner Sendromlarda İnsülin Benzeri Büyüme Faktörü-I ve İnsülin Benzeri Büyüme Faktörü Bağlayıcı Protein-3 Düzeyleri ve Prognozla İlişkisi

Cevad Şekuri1, Ece Onur2, Ozan Ütük3, Özgür Bayturan1, Özlem Arslan4, Uğur Kemal Tezcan5
1Özel Kent Hastanesi, Kardiyoloji Kliniği, İzmir
2Celal Bayar Üniversitesi Tıp Fakültesi,Biyokimya Anabilim Dalı, Manisa
3Department of Cardiology, School of Medicine, Celal Bayar University, Manisa, Turkey
4Department of Cardiology, Özel Doğuş Hospital, Mersin
5Celal Bayar Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Manisa

Anahtar Kelimeler: Akut koroner sendromu, insülin benzeri büyüme faktörü, ICF-bağlayıcı protein-3


Cevad Şekuri, Ece Onur, Ozan Ütük, Özgür Bayturan, Özlem Arslan, Uğur Kemal Tezcan. Serum Levels of Insulin-Like Growth Factor-1 and Insulin-Like Growth Factor Binding Protein-3 in Acute Coronary Syndromes and Relationship with Prognosis. Anatol J Cardiol. 2004; 4(3): 209-212


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