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Analysis of intra-aortic balloon pump model with ovine myocardial infarction [Anatol J Cardiol]
Anatol J Cardiol. 2009; 9(6): 492-498

Analysis of intra-aortic balloon pump model with ovine myocardial infarction

Mona Abdolrazaghi1, Mahdi Navidbakhsh2, Kamran Hassani3, Shahram Rabbani4, Hossein Ahmadi5
1Department of Mechanical Engineering, Alberta University, Edmonton, Canada
2Department of Mechanical Engineering, Iran University of Science and Technology, Tehran
3Department of Biomedical Engineering, Science and Research Branch, Ýslamic Azad University, Tehran
4Tehran Heart Research Center, Tehran
5Department of Cardiology, Tehran Medical University, Tehran

Objective: In this study, we have tried to model the effects of intra-aortic balloon pump (IABP) on myocardial infarction (MI) using the standardized data of MI in sheep which was obtained by ligation of the left anterior descending coronary artery. Methods: Mathematical model of whole cardiovascular system was presented in accordance to the arterial tree. The lumped parameter model was primarily obtained for a rigid vessel regarding the vessel diameter. In this study, the proper lumped model of every vessel was obtained by incorporating the rigid vessel lumped model into the capacitance as a compliance of the vessel. Intra-aortic balloon pump was modeled with the hemodynamic parameters of the aorta. It was assumed that balloon pump inflates at the beginning of the diastole and deflates near the beginning of the next systole. Results: During balloon pumping, the vessel diameter variation function counter pulsates sinusoidally with the same period of the cardiac cycle. End systolic pressure and end diastolic pressure decreases along with hemodynamic flow optimized through systemic arteries due to balloon pumping in diastole. It has been shown that the blood flow in subclavian artery increases as well. Moreover, the cardiac work keeps low, which prone to lower oxygen consumption. The results of modeling are in good agreement with IABP documentation. Conclusions: The presented model is a useful tool for studying of the cardiovascular system pathology and the presented modeling data are in good agreement with the experimental ones.

Keywords: Mathematical modeling, myocardial infarction, cardiovascular system, intra-aortic balloon pump, animal, disease model


Mona Abdolrazaghi, Mahdi Navidbakhsh, Kamran Hassani, Shahram Rabbani, Hossein Ahmadi. Analysis of intra-aortic balloon pump model with ovine myocardial infarction. Anatol J Cardiol. 2009; 9(6): 492-498


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