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Assessment of right ventricular function by isovolumic contraction acceleration before and after percutaneous closure of atrial septal defects: A preliminary study [Anatol J Cardiol]
Anatol J Cardiol. 2014; 14(5): 417-421 | DOI: 10.5152/akd.2014.4828  

Assessment of right ventricular function by isovolumic contraction acceleration before and after percutaneous closure of atrial septal defects: A preliminary study

Ali Rıza Akyüz1, Levent Korkmaz2, Turhan Turan1, Abdulkadir Kırış3, Hakan Erkan2, Mustafa Tarık Ağaç1, Muslihittin Emre Erkuş1, Şükrü Çelik1, Ramazan Akdemir4
1Clinic of Cardiology, Akçaabat Haçkalı Baba State Hospital; Trabzon-Turkey
2Clinic of Cardiology, Ahi Evren Thoracic and Cardiovascular Surgery Training and Research Hospital; Trabzon-Turkey
3Department of Cardiology, Faculty of Medicine, Karadeniz Technical University; Trabzon-Turkey.
4Department of Cardiology, Faculty of Medicine, Sakarya University; Sakarya-Turkey

Objective: The main purpose of present study was to investigate the impact of percutaneous closure of atrial septal defect (ASD) on right ventricular (RV) systolic function assessed by tricuspid annular isovolumic myocardial acceleration (IVA) that is independent of preload and afterload changes. Methods: A prospective cohort study was designed involving twenty five patients with secundum type ASD whom were successfully closed percutaneously between 2009 and 2011. Standard transthoracic echocardiography and tissue Doppler imaging were performed in all patients 12 to 24 hours before and one month after closure. Paired t test was performed to determine the statistical significance of variables before and after closure. Results: Significant decreases were observed in RV end-diastolic diameter, RV/left ventricular (LV) end-diastolic diameter ratio, right ventricular systolic myocardial velocity (Sm), right ventricular early myocardial velocity (Em) and right ventricular late myocardial velocity (Am) in the control echocardiography in the first month when compared with pre-procedure values. While significant increase was observed after procedure in right ventricular IVA (3.4±1.3 m/sec2 vs. 4.2±1.8 m/sec2, p=0.001), no significant change was observed in right ventricular global performance index, in right ventricular Em/Am ratio and left ventricular ejection fraction. Conclusion: Percutaneous closure of ASD resulted in recovery of right ventricular function as early as 1 month after closure.

Keywords: atrial septal defect, right ventricular function, transcatheter closure, tissue Doppler imaging, isovolumic acceleration


Ali Rıza Akyüz, Levent Korkmaz, Turhan Turan, Abdulkadir Kırış, Hakan Erkan, Mustafa Tarık Ağaç, Muslihittin Emre Erkuş, Şükrü Çelik, Ramazan Akdemir. Assessment of right ventricular function by isovolumic contraction acceleration before and after percutaneous closure of atrial septal defects: A preliminary study. Anatol J Cardiol. 2014; 14(5): 417-421


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