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The alteration of NTproCNP plasma levels following anaerobic exercise in physically active young men [Anatol J Cardiol]
Anatol J Cardiol. 2015; 15(2): 97-102 | DOI: 10.5152/akd.2014.5204  

The alteration of NTproCNP plasma levels following anaerobic exercise in physically active young men

Hilal Akseki Temür1, Selma Arzu Vardar1, Muzaffer Demir2, Orkide Palabıyık3, Aziz Karaca1, Zuhal Guksu1, Arif Ortanca4, Necdet Süt5
1Department of Physiology, Faculty of Medicine, Trakya University; Edirne-Turkey
2Department of Internal Medicine, Faculty of Medicine, Trakya University; Edirne-Turkey
3Department of Biophysics, Faculty of Medicine, Trakya University; Edirne-Turkey
4Faculty of Medicine, Trakya University; Edirne-Turkey
5Department of Biostatistics, Faculty of Medicine, Trakya University; Edirne-Turkey

Objective: Amino-terminal propeptide of C-type natriuretic peptide (NTproCNP) is a synthesis product of C-type natriuretic peptide (CNP). In this study, plasma levels of NTproCNP were compared before and after exercise in healthy young subjects who are physically active (PA) or not physically active (NPA).
 
Methods: The study was carried on PA group (n=10) who defined the exercise duration more than 2.5 hours per week for at least one year and NPA group (n=10) whose exercise duration was lower than 1.5 hours per week. The level of maximal oxygen consumption was determined. Wingate exercise test was applied on the following day. Plasma NTproCNP levels were measured before the exercise and at the 1st, 5th and 30th minute after the exercise.
 
Results: Exercise duration of physically active group was reported as 11.3±5.0 hours per week. Basal NTproCNP levels of the groups were found to be comparable. NTproCNP levels in the 5th minute (0.93±0.23 pmol/L; p<0.05) and in the 30th minute (0.77±0.21 pmol/L p<0.05) after exercise were higher than the levels before exercise (0.64±0.29 pmol/L) in PA group. Additionally, the plasma levels of NTproCNP after 5th minute of exercise were higher in PA group (0.93±0.23 pmol/L) than NPA group (0.74±0.16 pmol/L, p<0.05).
 
Conclusion: Being physically active may be a fact affecting the secretion of CNP, which plays a protective role in endothelium, following exercise. 
 

Keywords: amino-terminal propeptide of C-type natriuretic peptide, C-type natriuretic peptide, physical activity, exercise, endothelium, heart


Fiziksel olarak aktif olan genç erkeklerde plazma NTproCNP düzeyinde anaerobik egzersiz sonrası değişim

Hilal Akseki Temür1, Selma Arzu Vardar1, Muzaffer Demir2, Orkide Palabıyık3, Aziz Karaca1, Zuhal Guksu1, Arif Ortanca4, Necdet Süt5
1Department of Physiology, Faculty of Medicine, Trakya University; Edirne-Turkey
2Department of Internal Medicine, Faculty of Medicine, Trakya University; Edirne-Turkey
3Department of Biophysics, Faculty of Medicine, Trakya University; Edirne-Turkey
4Faculty of Medicine, Trakya University; Edirne-Turkey
5Department of Biostatistics, Faculty of Medicine, Trakya University; Edirne-Turkey

Amaç: Amino-terminal propeptid C-tipi natriüretik peptid (NTproCNP), C-tipi natriüretik peptidin bir sentez ürünüdür. Bu çalışmada fiziksel olarak aktif (FA) olan ve aktif olmayan (AO) sağlıklı gençlerde plazma NTproCNP düzeyinde egzersiz öncesi ve sonrası görülen değişim karşılaştırıldı.
 
Yöntemler: Çalışma, en az bir yıldan beri haftada 2.5 saatin üzerinde orta ve yoğun düzeyde egzersiz yapan FA grup (n=10) ve egzersiz süresi haftada 1.5 saatin altında olan AO grup (n=10) üzerinde yapıldı. Kişilerin maksimal oksijen tüketimi düzeyi belirlendi. Takip eden günde Wingate egzersiz testi uygulandı. Egzersiz öncesinde, egzersiz sonrası bir, beş ve otuzuncu dakikalarda plazma NTproCNP düzeyleri ölçüldü.
 
Bulgular: FA gruptaki ortalama egzersiz süresi haftada 11,3±5,0 saat olarak belirlendi. Egzersiz öncesi NTproCNP düzeyi gruplarda benzer bulundu. FA grupta, egzersiz sonrası beşinci dakikadaki (0,93±0,23 pmol/Lt; p<0,05) ve otuzuncu dakikadaki NTproCNP düzeyi (0,77±0,21 pmol/Lt p<0,05), egzersiz öncesinden (0,64±0,29 pmol/Lt) yüksekti. Ayrıca, FA grupta egzersiz sonrası beşinci dakikadaki NTproCNP düzeyi, AO gruptan (0,74±0,16 pmol/ Lt) daha yüksek bulundu (p<0,05).
 
Sonuç: Fiziksel olarak aktif olmak, endoteli koruyucu rol oynayan C-tipi natriüretik peptidin egzersiz sonrası salınımını etkileyen bir faktör olabilir. 

Anahtar Kelimeler: amino-terminal propeptid C-tipi natriüretik peptid, C-tipi natriüretik peptid, fiziksel aktivite, egzersiz, endotel, kalp.


Hilal Akseki Temür, Selma Arzu Vardar, Muzaffer Demir, Orkide Palabıyık, Aziz Karaca, Zuhal Guksu, Arif Ortanca, Necdet Süt. The alteration of NTproCNP plasma levels following anaerobic exercise in physically active young men. Anatol J Cardiol. 2015; 15(2): 97-102


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