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Antithrombotic treatment patterns and stroke prevention in patients with atrial fibrillation in TURKEY: inferences from GARFIELD-AF registry [Anatol J Cardiol]
Anatol J Cardiol. 2019; 21(5): 272-280 | DOI: 10.14744/AnatolJCardiol.2019.78178  

Antithrombotic treatment patterns and stroke prevention in patients with atrial fibrillation in TURKEY: inferences from GARFIELD-AF registry

Begüm Sayın1, Sercan Okutucu1, Mehmet Birhan Yılmaz2, Kurtuluş Özdemir3, Ali Aydınlar4, Durmuş Yıldıray Şahin5, Armağan Altun6, Sadık Açıkel7, Ertuğrul Okuyan8, Murat Sucu9, Zeki Öngen10, Murat Kazim Ersanlı11, Özcan Yılmaz12, Mesut Demir13, Hasan Pekdemir14, Ramazan Topsakal15, Mehmet Levent Şahiner16, Dursun Aras17, Ali Oto1
1Department of Cardiology, Memorial Ankara Hospital; Ankara-Turkey
2Department of Cardiology, Faculty of Medicine, Cumhuriyet University; Sivas-Turkey
3Department of Cardiology, Meram Faculty of Medicine, Konya Necmettin Erbakan University; Konya-Turkey
4Department of Cardiology, Faculty of Medicine, Uludağ University; Bursa-Turkey
5Department of Cardiology, Adana Numune Training and Research Hospital; Adana-Turkey
6Department of Cardiology, Başkent University İstanbul Health Practice and Research Center Hospital; İstanbul-Turkey
7Department of Cardiology, Ankara Dışkapı Yıldırım Beyazıt Education and Research Hospital; Ankara-Turkey
8Department of Cardiology, Bağcılar Training and Research Hospital; İstanbul-Turkey
9Department of Cardiology, Faculty of Medicine, Gaziantep University; Gaziantep-Turkey
10Department of Cardiology, Cerrahpaşa Faculty of Medicine, İstanbul University; İstanbul-Turkey
11Department of Cardiology, İstanbul University Cardiology Institute; İstanbul-Turkey
12Department of Cardiology, Faculty of Medicine, Ondokuz Mayıs University; Samsun-Turkey
13Department of Cardiology, Faculty of Medicine, Çukurova University; Adana-Turkey
14Department of Cardiology, Faculty of Medicine, İnönü University, Turgut Özal Medical Center; Malatya-Turkey
15Department of Cardiology, Faculty of Medicine, Erciyes University; Kayseri-Turkey
16Department of Cardiology, Faculty of Medicine, Hacettepe University; Ankara-Turkey
17Department of Cardiology, Türkiye Yüksek İhtisas Training and Research Hospital; Ankara-Turkey

The corner stone of atrial fibrillation therapy includes the prevention of stroke with less adverse effects. The Global Anticoagulant Registry in the FIELD–Atrial Fibrillation (GARFIELD-AF) study provided data to compare treatment strategies in Turkey with other populations and every-day practice of stroke prevention management with complications.Methods: GARFIELD-AF is a large-scale registry that enrolled 52,014 patients in five sequential cohorts at >1,000 centers in 35 countries.This study initiated to track the evolution of global anticoagulation practice, and to study the impact of NOAC therapy in AF. 756 patients from 17 enrolling sites in Turkey were in cohort 4 and 5.Treatment strategies at diagnosis initiated by CHA2DS2-VASc score, baseline characteristics of patients, treatment according to stroke and bleeding risk profiles, INR values were analyzed in cohorts.Also event rates during the first year follow up were evaluated.Results: AF patients in Turkey were mostly seen in young women.Stroke risk according to the CHADS2 score and CHA2DS2-VASc score compared with world data. The mean of risk score values including HAS-BLED score were lower in Turkey than world data.The percentage of patients receiving FXa inhibitor with or without an antiplatelet usage was more than the other drug groups. All-cause mortality was higher in Turkey. Different form world data when HAS-BLED score was above 3, the therapy was mostly changed to antiplatelet drugs in Turkey.Conclusion: The data of GARFIELD-AF provide data from Turkey about therapeutic strategies, best practices also deficiencies in available treatment options, patient care and clinical outcomes of patients with AF.

Keywords: atrial fibrillation, anticoagulation, stroke


Begüm Sayın, Sercan Okutucu, Mehmet Birhan Yılmaz, Kurtuluş Özdemir, Ali Aydınlar, Durmuş Yıldıray Şahin, Armağan Altun, Sadık Açıkel, Ertuğrul Okuyan, Murat Sucu, Zeki Öngen, Murat Kazim Ersanlı, Özcan Yılmaz, Mesut Demir, Hasan Pekdemir, Ramazan Topsakal, Mehmet Levent Şahiner, Dursun Aras, Ali Oto. Antithrombotic treatment patterns and stroke prevention in patients with atrial fibrillation in TURKEY: inferences from GARFIELD-AF registry. Anatol J Cardiol. 2019; 21(5): 272-280

Corresponding Author: Begüm Sayın, Türkiye


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