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Incidence, prognostic significance and Survival outcomes of Primary Cardiac Sarcoma: An Updated Population-Based Retrospective Study [Anatol J Cardiol]
Anatol J Cardiol. Ahead of Print: AJC-78107 | DOI: 10.14744/AnatolJCardiol.2020.78107  

Incidence, prognostic significance and Survival outcomes of Primary Cardiac Sarcoma: An Updated Population-Based Retrospective Study

M. Bakri Hammami1, Moh’d Zaki Al-wawi2, Huwaida Fazel1, MohamadAnas Oudih1
1Department of Clinical Sciences, College of Medicine, University of Sharjah, Sharjah, United Arab Emirates
2Rak College Of Medical Sciences, Ras Al Khaimah Medical And Health Sciences University, Ras Al Khaimah, United Arab Emirates

Background and purpose: Primary cardiac sarcoma is a rare entity with an aggressive course and a dim prognosis, comprising over 95% of all malignant cardiac tumors. Current knowledge about cardiac sarcoma is lacking owing to the sparsity of evidence. This paper aims to study the incidence and incidence-based rates of cardiac sarcoma, patient characteristics, treatment modalities and survival factors.
Methods: A retrospective analysis of the incidence, incidence-based mortality rates and characteristics of cardiac sarcoma, between 1975 and 2016, were calculated using the Surveillance, Epidemiology, and End Results (SEER) database. The National Cancer Institute’s Joinpoint Regression program was used to calculate the Annual Percentage Changes (APC). Univariate and multiple regression analysis were used to determine survival characteristics.
Results: 408 patients were identified for incidence analysis and 385 eligible patients were identified for survival analysis. The mean age at diagnosis was 46.3 (± 17.9) years. The incidence rate (per 100000 per year) of cardiac sarcoma within the indicated years was 0.22 with an increased Annual Percentage Change (APC) of 1.7 (p value = 0.013, 95% CI [0.5 – 2.9]). 251 patients (61.5%) underwent surgery, 93 patients (22.8%) received adjuvant radiotherapy and 197 patients (50.2%) received chemotherapy. Surgical resection, chemotherapy, stage of tumor and younger age significantly improved survival (p value < 0.001).
Conclusion: Cardiac sarcoma is a rare type of soft tissue sarcomas with a poor prognosis. The incidence of cardiac sarcoma has been increasing over the past 30 years. Surgery remains the mainstay of management. Further studies are needed

Keywords: SEER, Cardiac Sarcoma, Incidence, Survival, Population Study

Corresponding Author: M. Bakri Hammami, United Arab Emirates

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