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Speckle-tracking strain assessment of left ventricular dysfunction in synthetic cannabinoid and heroin users [Anatol J Cardiol]
Anatol J Cardiol. 2018; 19(6): 388-393 | DOI: 10.14744/AnatolJCardiol.2018.76429  

Speckle-tracking strain assessment of left ventricular dysfunction in synthetic cannabinoid and heroin users

Aykut Demirkıran1, Neslihan Albayrak1, Yakup Albayrak2, Cafer Sadık Zorkun3
1Department of Cardiology, Tekirdağ Çorlu State Hospital; Tekirdağ-Turkey
2Department of Psychiatry, Faculty of Medicine, Namık Kemal University; Tekirdağ-Turkey
3Department of Cardiology, Faculty of Medicine, Trakya University; Edirne-Turkey

Objective: There is growing evidence regarding the numerous adverse effects of synthetic cannabinoids (SCBs) on the cardiovascular system; however, no studies have shown the cardiovascular effects of opioids using strain echocardiography. This study examines the cardiac structure and function using echocardiographic strain imaging in heroin and synthetic cannabinoid users.
Methods: This double-blind study included patients who were admitted or referred to a rehabilitation center for heroin (n=31) and synthetic cannabinoid users (n=30). Heroin users and synthetic cannabinoid users were compared with healthy volunteers (n=32) using two-dimensional (2D) speckle-tracking (ST) echocardiography.
Results: No differences were found in the baseline characteristics and 2D echocardiography values. The mean global longitudinal strain value was −20.5%±2.4% for SCB users, −22.3%±2.4% for opioid users, and −22.5%±2.2% for healthy volunteers (p=0.024). The mean apical 2-chamber (AP2C) L-strain values were −20.1%±3.1%, −22.4%±3.0%, and −22.3%±2.8% for SCB users, opioid users, and healthy volunteers, respectively (p=0.032). The mean apical 4-chamber (AP4C) L-strain values were −20.7%±2.5% for SCB users, −23.2%±3.2% for opioid users, and −23.8%±3.1% for healthy volunteers (p<0.001).
Conclusion: SCBs are potential causes of subclinical left ventricular dysfunction.

Keywords: strain, left ventricular function, synthetic cannabinoid, heroin


Aykut Demirkıran, Neslihan Albayrak, Yakup Albayrak, Cafer Sadık Zorkun. Speckle-tracking strain assessment of left ventricular dysfunction in synthetic cannabinoid and heroin users. Anatol J Cardiol. 2018; 19(6): 388-393

Corresponding Author: Aykut Demirkıran, Türkiye


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