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Effects of beta-blockers on transmitral, pulmonary venous flows, and spontaneous echo-contrast grades in heart failure [Anatol J Cardiol]
Anatol J Cardiol. 2005; 5(3): 178-181

Effects of beta-blockers on transmitral, pulmonary venous flows, and spontaneous echo-contrast grades in heart failure

Sait Mesut Doğan1, Mustafa Aydın2, Metin Gürsürer1, Aydın Dursun1, Fatih Çam3, Tolga Onuk1, Hediye Madak1
1Zonguldak Karaelmas Üniversitesi, Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Zonguldak, Türkiye
2Department of Cardiology, Faculty of Medicine, Zonguldak Karaelmas University, Zonguldak, Turkey
3Clinic of Cardiology, Aydın Medline Hospital, Aydın-Turkey

Objective: In this study, we aimed to investigate effects of metoprolol treatment on transmitral, pulmonary venous flows and spontaneous echo contrast in patients with heart failure. Methods: Twenty-four patients (mean age: 55±8 years) with heart failure were enrolled to the study. All were given metoprolol succinate with titrated target dose of 50 mg/d controlled release tablets for 1 month. Transmitral flow and pulmonary venous flow, systolic, diastolic and atrial reversal flow velocities were measured, and compared with the pretreatment values. Results: Heart rate significantly decreased. No significant change was observed in ejection fraction. When the post treatment values were compared with the pretreatment values, it was detected that isovolumetric relaxation time significantly decreased (p<0.05), mitral E wave and E/A ratio were significantly increased (p<0.05 and p<0.05, respectively) after the treatment. A significant increase was observed in pulmonary vein systolic velocity after metoprolol treatment (p<0.05). Conclusion: Metoprolol treatment can cause an improvement in transmitral and pulmonary venous flows.

Keywords: Heart failure, transmitral flow, pulmonary venous flow, spontaneous echo contrast, metoprolol


Sait Mesut Doğan, Mustafa Aydın, Metin Gürsürer, Aydın Dursun, Fatih Çam, Tolga Onuk, Hediye Madak. Effects of beta-blockers on transmitral, pulmonary venous flows, and spontaneous echo-contrast grades in heart failure. Anatol J Cardiol. 2005; 5(3): 178-181


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