ISSN 2149-2263 | E-ISSN 2149-2271 Home      
 
Volume : 21 Issue : 4
Current Issue Archive Popular Article Ahead of Print

   
Quick Search





 
Gender disparities in heart failure with mid-range and preserved ejection fraction: Results from APOLLON study [Anatol J Cardiol]
Anatol J Cardiol. Ahead of Print: AJC-71954 | DOI: 10.14744/AnatolJCardiol.2019.71954  

Gender disparities in heart failure with mid-range and preserved ejection fraction: Results from APOLLON study

Bülent Özlek1, Eda Özlek1, Serkan Kahraman2, Mehmet Tekinalp3, Hicaz Zencirkiran Agus2, Oğuzhan Çelik1, Cem Çil1, Volkan Doğan1, Özcan Başaran1, Bedri Caner Kaya4, Ibrahim Rencüzoğulları5, Altuğ Ösken6, Lütfü Bekar7, Ozan Çakır8, Yunus Çelik9, Kadir Uğur Mert10, Kadriye Memiç Sancar2, Samet Sevinç2, Gurbet Özge Mert11, Murat Biteker1
1Department of Cardiology, Muğla Sıtkı Koçman University Training and Research Hospital; Muğla-Turkey
2Department of Cardiology, Mehmet Akif Ersoy Thoracic and Cardiovascular Surgery Training and Research Hospital; İstanbul-Turkey
3Department of Cardiology, Kahramanmaraş Necip Fazıl City Hospital, Kahramanmaraş-Turkey
4Department of Cardiology, Mehmet Akif İnan Training and Research Hospital; Şanlıurfa-Turkey
5Department of Cardiology, Faculty of Medicine, Kafkas University; Kars-Turkey
6Department of Cardiology, Dr. Siyami Ersek Thoracic and Cardiovascular Surgery Training and Research Hospital; İstanbul-Turkey
7Department of Cardiology, Hitit University Çorum Erol Olçok Training and Research Hospital; Çorum-Turkey
8Department of Cardiology, Faculty of Medicine, Bülent Ecevit Universiy; Zonguldak-Turkey
9Department of Cardiology, Kırıkkale Yüksek İhtisas Hospital; Kırıkkale-Turkey
10Department of Cardiology, Faculty of Medicine, Eskişehir Osmangazi University; Eskişehir-Turkey
11Department of Cardiology, Yunus Emre State Hospital; Eskişehir-Turkey

Objective: This study aimed to examine gender-based differences in epidemiology, clinical characteristics, and management of consecutive patients with heart failure with mid-range ejection fraction (HFmrEF) and heart failure with preserved ejection fraction (HFpEF).
Methods: The APOLLON trial (A comPrehensive, ObservationaL registry of heart faiLure with mid-range and preserved ejection fractiON) is a
multicenter, cross-sectional, and observational study. Consecutive patients with HFmrEF or HFpEF who were admitted to the cardiology clinics were included (NCT03026114). Herein, we performed a post-hoc analysis of data from the APOLLON trial.
Results: The study population included 1065 (mean age of 67.1±10.6 years, 54% women) patients from 11 sites in Turkey. Compared with men, women were older (68 years vs. 67 years, p<0.001), had higher body mass index (29 kg/m2 vs. 27 kg/m2, p<0.001), and had higher heart rate (80 bpm vs. 77.5 bpm, p<0.001). Women were more likely to have HFpEF (82% vs. 70.9%, p<0.001), and they differ from men having a higher prevalence of hypertension (78.7% vs. 73.2%, p=0.035) and atrial fibrillation (40.7% vs. 29.9%, p<0.001) but lower prevalence of coronary artery disease (29.5% vs. 54.9%, p<0.001). Women had higher N-terminal pro-B-type natriuretic peptide (691 pg/mL vs. 541 pg/mL, p=0.004), lower hemoglobin (12.7 g/dL vs. 13.8 g/dL, p<0.001), and serum ferritin (51 ng/mL vs. 64 ng/mL, p=0.001) levels, and they had worse diastolic function (E/e'=10 vs. 9, p<0.001). The main cause of heart failure (HF) in women was atrial fibrillation, while it was ischemic heart disease in men.
Conclusion: Clinical characteristics, laboratory findings, and etiological factors are significantly different in female and male patients with HFmrEF and HFpEF. This study offers a broad perspective for increased awareness about this patient profile in Turkey.

Keywords: clinical features, differences, gender, heart failure with mid-range ejection fraction, heart failure with preserved ejection fraction




Corresponding Author: Bülent Özlek, Türkiye


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar




 
 
KARE Publishing | Copyright © 2018 Turkish Society of Cardiology