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Evaluation of Tpe interval, Tpe/QT ratio, and Tpe/QTc ratio in patients with Behets disease [Anatol J Cardiol]
Anatol J Cardiol. 2019; 22(2): 85-90 | DOI: 10.14744/AnatolJCardiol.2019.70019  

Evaluation of Tpe interval, Tpe/QT ratio, and Tpe/QTc ratio in patients with Behets disease

ho Hidayet1, Vahit Demir2, Yaar Turan2, Glhan Grel3, Mehmet Hakan Taolar1
1Department of Cardiology, Faculty of Medicine, nnü University; Malatya-Turkey
2Department of Cardiology, Faculty of Medicine, Bozok University, Yozgat-Turkey
3Department of Dermatology, Faculty of Medicine, Bozok University, Yozgat-Turkey

Objective: Behet's disease (BD), a multisystemic inflammatory disorder, has been associated with a number of cardiovascular dysfunctions, including ventricular arrhythmias and sudden cardiac death. The mechanism of increased ventricular arrhythmias in BD remains uncertain. The aim of the present study was to assess the ventricular repolarization by using the Tpe interval, Tpe/QT ratio, and Tpe/QTc ratio as candidate markers of ventricular arrhythmias in patients with BD.
Methods: A total of 42 patients (mean age: 42.7110.99 years) with BD and 50 sex- and age-matched healthy volunteers (mean age: 39.2411.32 years) as the control group were evaluated. The risk of ventricular arrhythmia was evaluated by calculating the electrocardiographic, the Tpe interval, and the QT, QTc, Tp e/QT, and Tpe/QTc ratios.
Results: QTmax (p=0.005), QTcmax (p=0.015), QTmin (p=0.011), and QTcmin (p=0.024) were statistically significantly higher in the BD group than in the control group. The Tpe, cTpe, Tpe/QT, and Tpe/QTc ratios were also significantly higher in patients with BD than in the control group (80.264.55 and 74.746.47, respectively, p<0.001; 88.236.36 and 82.687.81, respectively, p<0.001; 0.210.01 and 0.200.01, respectively, p=0.008; and 0.190.01 and 0.180.01, respectively, p=0.01). Positive correlations were found between Tpe/QTc ratio and disease duration (r=0.382, p=0.013).
Conclusion: Our study showed that the Tpe interval, Tpe/QT ratio, and Tpe/QTc ratio, which are evaluated electrocardiographically in patients with BD, have been prolonged compared with normal healthy individuals. A positive correlation was determined between disease duration and Tpe/QTc ratio. These results may be indicative of an early subclinical cardiac involvement in patients with BD, considering the duration of the disease. Therefore, these patients should be more closely screened for ventricular arrhythmias.

Keywords: Behets disease, Tpe interval, Tpe/QTd ratio, ventricular arrhythmia


ho Hidayet, Vahit Demir, Yaar Turan, Glhan Grel, Mehmet Hakan Taolar. Evaluation of Tpe interval, Tpe/QT ratio, and Tpe/QTc ratio in patients with Behets disease. Anatol J Cardiol. 2019; 22(2): 85-90

Corresponding Author: ho Hidayet, Trkiye


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