ISSN 2149-2263 | E-ISSN 2149-2271 Home      
 
Volume : 21 Issue : 3
Current Issue Archive Popular Article Ahead of Print

   
Quick Search





 
Association of rs17042171 with chromosome 4q25 with atrial fibrillation in Chinese Han populations [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(3): 165-169 | DOI: 10.5152/akd.2015.5999  

Association of rs17042171 with chromosome 4q25 with atrial fibrillation in Chinese Han populations

Liyan Zhao, Xin-guang Chen, Yaowu Liu, Zhen Fang, Fengxiang Zhang
Section Of Pacing And Electrophysiology, Division Of Cardiology, The First Affiliated Hospital Of Nanjing Medical University; Nanjing- China

Objective: A recent genome-wide association study (GWAS) identified a susceptibility single nucleotide polymorphism (SNP), rs17042171 on 4q25 for atrial fibrillation (AF). The aim of the present study was to investigate whether this association between rs17042171 and AF also exists in Chinese Han populations.
Methods: It was a case-control study. We enrolled a total of 1,593 Chinese Han origin individuals in the study, including 597 AF patients and 996 AF-free controls. Genotyping was performed using the TaqMan allelic discrimination Assay. Odds ratios (ORs) and 95% confidence intervals (CIs) were calculated in logistic regression models.
Results: There was strongly significant difference between AF patients and control subjects regarding rs17042171 assumption of additive model (OR=2.20, 95% CI: 1.88-2.57, p=2.00 10-22), dominant model (OR=2.99; 95% CI: 2.19-4.09; p=6.47 10-12) and a recessive (OR=2.75; 95% CI: 2.21-3.43; p=1.30 10-19). In the stratification analysis based on age, gender, hypertension, diabetes and coronary artery disease, there was no significant difference of the associations for rs17042171 among the subgroups.
Conclusion: Our results indicated that rs17042171 confers an increased risk of AF in Chinese Han Populations and expanded the association to non-European ancestry populations for the first time. (Anatol J Cardiol 2016; 16: 165-9)

Keywords: atrial fibrillation, genetics, single nucleotide polymorphism, rs17042171


Liyan Zhao, Xin-guang Chen, Yaowu Liu, Zhen Fang, Fengxiang Zhang. Association of rs17042171 with chromosome 4q25 with atrial fibrillation in Chinese Han populations. Anatol J Cardiol. 2016; 16(3): 165-169

Corresponding Author: Fengxiang Zhang, China


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar




 
 
KARE Publishing | Copyright 2018 Turkish Society of Cardiology