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Hypotensive effect of alpha-lipoic acid after a single administration in rats [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(5): 306-309 | DOI: 10.5152/AnatolJCardiol.2015.6217  

Hypotensive effect of alpha-lipoic acid after a single administration in rats

Magdalena Dudek1, Katarzyna Razny2, Anna Bilska - Wilkosz3, Malgorzata Iciek3, Jacek Sapa2, Lidia Wlodek3, Barbara Filipek1
1Department Of Pharmacodynamids, Jagiellonian University, Collegium Medicum; Kraków- Poland
2Department Of Pharmacological Screening, Jagiellonian University, Collegium Medicum; Kraków- Poland
3Chair Of Medical Biochemistry, Jagiellonian University, Medical College; Kraków- Poland

Objective: The effect of alpha-lipoic acid on blood pressure was investigated many times in chronic studies, but there are no studies on the effect of this compound after a single administration. Alpha-lipoic acid is a drug used in diabetic neuropathy, often in obese patients, to treat hypertension. Therefore, knowledge of the potential antihypertensive effect of alpha-lipoic acid even after a single dose and possibly too much pressure reduction is interesting and useful.
Methods: The mechanism of the hypotensive effect of alpha-lipoic acid was examined in normotensive rats in vivo after a single intraperitoneal administration, blood pressure in the left carotid artery of the rats was measured prior to the administration of the compounds (alphalipoic acid and/or glibenclamide) and 80 min thereafter.
Results: Alpha-lipoic acid at a dosage of 50 mg/kg b.w. i.p. significantly decreased the blood pressure from the 50th min after drug administration. This cardiovascular effect of this compound was reversed by glibenclamide, a selective KATP blocker. Glibenclamide alone at this dose did not significantly affect the blood pressure. Statistical significance was evaluated using two-way ANOVA.
Conclusion: This suggests that alpha-lipoic acid affects ATP-dependent potassium channels. It is possible that this is an indirect effect of hydrogen sulfide because alpha-lipoic acid can increase its concentration. The results obtained in this study are very important because the patients taking alpha-lipoic acid may be treated for co-existing hypertension. Therefore, the possibility of blood pressure lowering by alphalipoic acid should be taken into account, although it does not lead to excessive orthostatic hypotension. (Anatol J Cardiol 2016; 16: 306-9)

Keywords: alpha-lipoic acid, blood pressure, hydrogen sulfide, KATP channels

Magdalena Dudek, Katarzyna Razny, Anna Bilska - Wilkosz, Malgorzata Iciek, Jacek Sapa, Lidia Wlodek, Barbara Filipek. Hypotensive effect of alpha-lipoic acid after a single administration in rats. Anatol J Cardiol. 2016; 16(5): 306-309

Corresponding Author: Magdalena Dudek, Poland

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