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Assessment of cardio-ankle vascular index in patients with cardiac syndrome-X: an observational study [Anatol J Cardiol]
Anatol J Cardiol. 2013; 13(8): 766-771 | DOI: 10.5152/akd.2013.263  

Assessment of cardio-ankle vascular index in patients with cardiac syndrome-X: an observational study

Ahmet Çağrı Aykan1, Tayyar Gökdeniz1, İlker Gül1, Faruk Boyacı1, Turhan Turan2, Duygun Altıntaş Aykan3, Şükrü Çelik1, Mustafa Yıldız4
1Clinic of Cardiology, Ahi Evren Chest and Cardiovascular Surgery Education and Research Hospital, Trabzon-Turkey
2Clinic of Cardiology, Akçabat Haçkalıbaba State Hospital, Trabzon-Turkey
3Department of Pharmacology, Faculty of Medicine, Karadeniz Technical University, Trabzon-Turkey
4Department of Cardiology, İstanbul University Haseki Cardiology Institute, İstanbul-Turkey

Objective: Arterial stiffness is associated with major adverse cardiovascular events. Cardio-ankle vascular index (CAVI), a novel marker of arterial stiffness, which is weakly influenced by systolic blood pressure, is a sensitive marker the atherosclerosis and arteriolosclerosis. The aim of this study is to investigate arterial stiffness by CAVI in patients with cardiac syndrome X (CSX). Methods: The present study was observational and cross sectional, and involved 49 patients (26 male) with CSX (angina-like chest pain, positive electrocardiographic ischemic changes at treadmill exercise test, angiographically normal coronary arteries) and 54 healthy subjects (21 male). CAVI was measured by VaSera-1000 CAVI instrument. Statistical analysis was performed using the Chi-square, Student t-test, correlation analysis and logistic regression analysis. Results: The CAVI and pulse pressure were significantly increased in patients with CSX compared to control group (7.50±1.50, 6.49±0.77, p<0.001; 53.00±10.06, 47.39±8.17, p=0.002, consecutively). In contrast, there were no significant differences in the age, weight, height, body mass index, waist circumference, hip circumference, systolic blood pressure, diastolic blood pressure, mean blood pressure, glucose, low density lipoprotein level, high density lipoprotein level (HDL), triglyceride, estimated creatinine clearance, hemoglobin, left atrium diameter, left ventricular mass (LVM), LVM index and ejection fraction. CAVI was the only independent predictor of CSX in logistic regression analysis (OR=1.780, 95% CI: 1.157-2.737, p=0.009). Conclusion: CAVI is increased in syndrome X patients and is an independent predictor of this syndrome.

Keywords: CAVI, arterial stiffness, cardiac syndrome X, coronary, angiography, regression analysis


Ahmet Çağrı Aykan, Tayyar Gökdeniz, İlker Gül, Faruk Boyacı, Turhan Turan, Duygun Altıntaş Aykan, Şükrü Çelik, Mustafa Yıldız. Assessment of cardio-ankle vascular index in patients with cardiac syndrome-X: an observational study. Anatol J Cardiol. 2013; 13(8): 766-771


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