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Cannabis and tramadol addiction: Do they imply additive risk for acute myocardial infarction in adults younger than 45 years? [Anatol J Cardiol]
Anatol J Cardiol. Ahead of Print: AJC-67206 | DOI: 10.14744/AnatolJCardiol.2020.67206  

Cannabis and tramadol addiction: Do they imply additive risk for acute myocardial infarction in adults younger than 45 years?

Hazem Mansour1, Mona Rayan1, Mina Shnoda2, Diaa Kamal1
1Departement of cardiology, Ain shams university, Cairo,Egypt
2Allegheny general hospital,United states of America

Objective:
Acute myocardial infarction(AMI)is the leading cause of cardiovascular events world-wide. It is common in elderly because of atherosclerotic process which is related to the usual risk factors.The ensuing rupture of atheromatous plaque with deleterious sequel is the usual etiology of the disease. However, in youth there are less studied etiological factors other than the usual ones. So we aimed to investigate the risk profile in Egyptian youth presented with AMI.
Methods:
A study was done on 106 patients aged ≤45 years admitted with AMI in our University hospital to explore their clinical profile,risk factors.
Results:
71 patients presented by STEMI (67%),while 35 patients presented by NSTEMI (33%).Anterior wall MI was predominant in 49 patients (46.2%).93 patients (88%) were smokers,31 patients (29.2%) were tramadol users, 43 patients(40.6%) smoked cannabis, 50 patients (47.2%) had bad sleeping habits,29 patients (27.4%) had high stress levels, 37 patients (34.9%) were hypertensive,22 patients were diabetic (20.8%). Family history of coronary artery disease (CAD )was present in 20 (18.9%) patients. Low HDL was seen in 47 patients (44.3%),high LDL in 20 patients (18.9%). Left anterior descending artery(LAD)was involved in 56 % of patients,with an evident association with tramadol use.We found a significant association between both tramadol use& Cannabis smoking and the presence of heavy thrombus burden in Coronary Angiography(CA).

Conclusion
AMI in Egyptian youth was predominant in males and anterior STEMI was the most common presentation.Cannabis,tramadol addiction imply paramount hazardous factors for AMI in the Egyptian youth

Keywords: Acute Myocardial Infarction(AMI), youth, risk factors, cannabis, tramadol.




Corresponding Author: Hazem Mansour, Egypt


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