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Triple therapy (aspirin, clopidogrel and oral anticoagulant) after percutaneous coronary intervention: another call for personalized medicine [Anatol J Cardiol]
Anatol J Cardiol. 2013; 13(5): 486-494 | DOI: 10.5152/akd.2013.147  

Triple therapy (aspirin, clopidogrel and oral anticoagulant) after percutaneous coronary intervention: another call for personalized medicine

Azra Tanrıkulu1, Mehmet Ağırbaşlı2
1Clinic of Cardiology, Tarsus Umut Surgical Medical Center, Tarsus-Turkey
2Department of Cardiology, Faculty of Medicine, Marmara University, İstanbul-Turkey

Studies indicate that 5-7% patients undergoing percutaneous coronary intervention (PCI) have an indication for anticoagulation therapy. Most commonly atrial fibrillation (AF) is the indication. These subjects require triple therapy with aspirin, clopidogrel, and an oral anticoagulant (OAC). Several questions, concerns and challenges exist regarding the duration, benefit, risks and alternatives related to triple therapy. These questions constitute a moving target with recently approved antiplatelet and anticoagulant agents. This brief review will summarize the current literature regarding triple therapy, potential solutions that can mitigate the formidable risk of bleeding. Arising from that discussion, a logical consensus can be developed that should be applicable to studies with novel agents that interfere with homeostasis. The ultimate goal is to enhance cardiovascular outcome and decrease thrombotic and bleeding complications.

Keywords: Triple therapy, dual antiplatelet therapy, percutaneous coronary stenting, atrial fibrillation, bleeding complications


Azra Tanrıkulu, Mehmet Ağırbaşlı. Triple therapy (aspirin, clopidogrel and oral anticoagulant) after percutaneous coronary intervention: another call for personalized medicine. Anatol J Cardiol. 2013; 13(5): 486-494


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