ISSN 2149-2263 | E-ISSN 2149-2271 Home      
 
Volume : 22 Issue : 1
Current Issue Archive Popular Article Ahead of Print

   
Quick Search





 
Heart rate variability and heart rate turbulence in patients with polycystic ovary syndrome [Anatol J Cardiol]
Anatol J Cardiol. 2016; 16(5): 323-327 | DOI: 10.5152/AnatolJCardiol.2015.6307  

Heart rate variability and heart rate turbulence in patients with polycystic ovary syndrome

Gülay Özkeçeci1, Bekir Serdar Ünlü2, Hüseyin Dursun3, Önder Akçi1, Gülengül Köken2, Ersel Onrat1, Alaettin Avşar1
1Departments Of Cardiology, Aculty Of Medicine, Afyon University; Afyonkarahisar- Turkey
2Gynecology And Obstetrics, Faculty Of Medicine, Afyon University; Afyonkarahisar- Turkey
3Department Of Cardiology, Faculty Of Medicine, Dokuz Eylül University; İzmir- Turkey

Objective: Cardiac autonomic dysfunction may develop in patients with polycystic ovary syndrome (PCOS). Heart rate variability (HRV) and heart rate turbulence (HRT) are used in assessing cardiac autonomic functions. The goal of this study was to compare the cardiac autonomic functions in patients with PCOS and healthy controls. To our knowledge, this is the first study evaluating cardiac autonomic functions in patients with PCOS with respect to both HRV and HRT.
Methods: Twenty-three patients with PCOS (mean age 22.8±3.9 years) and 25 healthy female volunteers who were matched for age and body mass index (BMI) (mean age 23.5±6.2 years) were enrolled in this as case-control study. Twenty-four hour ambulatory electrocardiogram recordings of all participants were taken using Pathfinder software. The time domain parameters of HRV and HRT, including turbulence onset (TO) and turbulence slope, were calculated. Diagnosis of PCOS was made with physical and laboratory findings of hirsutism or biochemical hyperandrogenism and chronic anovulation. Diabetes mellitus, other hormon disorders or hormon therapy, pregnancy, atrial fibrilation, obesite, chronic diseases, disorders of the autonomic nervous system, a history of drug use affecting the autonomic nervous system were excluded.
Results: There were no significant differences in HRV and HRT parameters between the two groups. Cardiovascular risk factors, such as BMI, blood pressure, fasting blood glucose, and lipid parameters, were also similar. Triangular index measure of HRV was negatively correlated with high density lipoprotein cholesterol levels (r=-0.47, p<0.05), while age and BMI were significantly correlated with TO (r=0.31 and 0.47, respectively; p<0.05 for all).
Conclusion: Cardiac autonomic functions were not found to be altered in patients with PCOS in comparison with healthy controls. These results may be explained with the absence of concomitant cardiovascular risk factors with the patients being in the early stage of the disease. (Anatol J Cardiol 2016; 16: 323-27)

Keywords: cardiac autonomic function, polycystic ovary syndrome, heart rate turbulence, heart rate variability


Gülay Özkeçeci, Bekir Serdar Ünlü, Hüseyin Dursun, Önder Akçi, Gülengül Köken, Ersel Onrat, Alaettin Avşar. Heart rate variability and heart rate turbulence in patients with polycystic ovary syndrome. Anatol J Cardiol. 2016; 16(5): 323-327

Corresponding Author: Gülay Özkeçeci, Türkiye


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar




 
 
KARE Publishing | Copyright © 2018 Turkish Society of Cardiology