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The concentration of interleukin-33 in heart failure with reduced ejection fraction [Anatol J Cardiol]
Anatol J Cardiol. 2019; 21(6): 305-313 | DOI: 10.14744/AnatolJCardiol.2019.64614  

The concentration of interleukin-33 in heart failure with reduced ejection fraction

Oliwia Anna Segiet1, Ewa Romuk2, Ewa Nowalany-Kozielska1, Celina Wojciechowska1, Adam Piecuch3, Romuald Wojnicz3
1Department of 2nd Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia; Katowice-Poland
2Department of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia; Katowice-Poland
3Department of Histology and Cell Pathology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia; Katowice-Poland

Objective: Despite several improvements in the management of heart failure (HF), it is still an incurable and a progressive disease. Several trials demonstrated that the process of inflammation may be responsible for initiation and progression of HF. The aim of the present study was to investigate the role of interleukin-33 (IL-33) in the pathogenesis of HF and to assess whether disease etiology and course of the disease affect the expression of cytokines.
Methods: The study included 155 (106 male and 49 female) patients with systolic HF with a mean left ventricle ejection fraction of 32.1312.8% and 60 (36 male and 24 female) healthy individuals. IL-33 concentrations were evaluated using enzyme-linked immunosorbent assay.
Results: The concentration of IL-33 was statistically significantly lower in patients with HF than in healthy subjects, 16.91 (081.00) pg/mL and 92.51 (33.61439.61) pg/mL, respectively. Patients with HF with ischemic etiology had lower concentration of IL-33 (10.75 pg/mL) than subjects with HF with non-ischemic etiology (21.05 pg/mL). Patients with stable HF (10.46 pg/mL) had lower IL-33 levels than those with unstable HF (19.02 pg/mL).
Conclusion: The concentrations of IL-33 were lower in patients with HF than in healthy controls, which may play an important role of above cytokine in HF development and progression. In addition, interleukin concentrations varied depending on the etiology and severity of the course of the disease.

Keywords: heart failure, interleukin-33, immune system


Oliwia Anna Segiet, Ewa Romuk, Ewa Nowalany-Kozielska, Celina Wojciechowska, Adam Piecuch, Romuald Wojnicz. The concentration of interleukin-33 in heart failure with reduced ejection fraction. Anatol J Cardiol. 2019; 21(6): 305-313

Corresponding Author: Oliwia Anna Segiet, Poland


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