ISSN 2149-2263 | E-ISSN 2149-2271 Home      
 
Volume : 21 Issue : 5
Current Issue Archive Popular Article Ahead of Print

   
Quick Search





 
The concentration of interleukin-33 in heart failure with reduced ejection fraction [Anatol J Cardiol]
Anatol J Cardiol. Ahead of Print: AJC-64614 | DOI: 10.14744/AnatolJCardiol.2019.64614  

The concentration of interleukin-33 in heart failure with reduced ejection fraction

Oliwia Anna Segiet1, Ewa Romuk2, Ewa Nowalany-Kozielska1, Celina Wojciechowska1, Adam Piecuch3, Romuald Wojnicz3
12nd Department of Cardiology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland
2Department of Biochemistry, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland
3Department of Histology and Cell Pathology, School of Medicine with the Division of Dentistry in Zabrze, Medical University of Silesia, Katowice, Poland

Background: Despite several improvements in the management of heart failure (HF), it is still an incurable and a progressive disease. Several trials demonstrated that the process of inflammation may be responsible for the initiation and progression of HF. The aim of this study was to investigate the role of interleukin-33 (IL-33) in the pathogenesis of heart failure, and to assess whether disease etiology and course of the disease affect the expression of cytokines.
Material and Methods: The study included 155 patients with systolic HF (106 men and 49 women), with mean left ventricle ejection fraction 32.13 12.8% and 60 healthy people (36 men and 24 women). IL-33 concentrations were evaluated using enzyme-linked immunosorbent assay (ELISA).
Results: The concentration of interleukin-33 was statistically significantly decreased in patients with heart failure compared to healthy subjects, 16.91 (0 - 81.00) pg/ml and 92.51 (33.61 - 439.61) pg/ml, respectively. Patients with HF with ischemic etiology had lower concentration of interleukin-33 (10.75 pg /ml) than subjects with heart failure with non-ischemic etiology (21.05 pg/ml). Patients with stable heart failure (10.46 pg/ml) had lower IL-33 levels than unstable heart failure (19.02 pg/ml).
Conclusions: The concentrations of IL-33 were lower in HF patients compared to healthy controls, which may indicate an important role of above cytokine in HF development and progression. In addition, interleukin concentrations varied depending on the etiology and severity of the course of the disease.

Keywords: heart failure, interleukin-33, immune system




Corresponding Author: Oliwia Anna Segiet, Poland


TOOLS
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share
Send email to author

Similar articles
PubMed
Google Scholar




 
 
KARE Publishing | Copyright 2018 Turkish Society of Cardiology