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Echocardiographic evaluation of systolic and diastolic heart function in patients suffering from beta-thalassemia major aged 5-10 years at the Zahedan Research Center for Children and Adolescent Health [Anatol J Cardiol]
Anatol J Cardiol. 2010; 10(2): 150-153 | DOI: 10.5152/akd.2010.041  

Echocardiographic evaluation of systolic and diastolic heart function in patients suffering from beta-thalassemia major aged 5-10 years at the Zahedan Research Center for Children and Adolescent Health

Noor Mohammad i1, Semira Mehralizadeh2
1Department of Pediatric Cardiology, Zahedan University of Medical Sciences, Zahedan
2Department of Pediatric Cardiology, Semnan University of Medical Sciences, Semnan

Objective: Cardiac complications are the major cause of morbidity and mortality in beta-thalassemia major. The aim of the study was to evaluate right (RV) and left (LV) ventricular systolic and diastolic functions using myocardial performance index in young, asymptomatic children suffering from thalassemia major, for early detection of cardiac function impairment, preventing further cardiac damage by modifying disease progression and treatment. Methods: A case-controlled, cross-sectional study involving 80 patients suffering from beta- thalassemia major and 80 children adjusted in terms of age and sex served as a control group were studied in Research Center for Children and Adolescent Health Zahedan. The relevant echocardiographic parameters were measured in both subject groups: myocardial performance index (MPI), isovolumic relaxation time (IRT), isovolumic contraction time (ICT), pre-ejection period (PEP), ejection time (ET), PEP/ET ratio, deceleration time (DT) and acceleration time (AT). Data were analyzed by unpaired Student t test. Results: The left ventricular mean IRT in the patient group was 11421 and in the control group 9410 msec (p<0.05). The mean MPI (LV) in the patient group was 0.580.18 and in the control group 0.410.08 (p<0.05). The mean ET (LV) in the patient group was 23736 msec and in the control group 26625 msec (p<0.05). The mean ET (RV) in the patient group was 23739 msec and in the control group 26136 msec (p<0.05). Conclusion: There is an early systolic and diastolic dysfunction in children younger than 10 years with beta-thalassemia major. Even in young asymptomatic children with beta-thalassemia major, serial echocardiography seems warranted in order to adjust cardioprotective therapy.

Keywords: Beta-thalassemia major, systolic function, diastolic function, echocardiography, children


Noor Mohammad i, Semira Mehralizadeh. Echocardiographic evaluation of systolic and diastolic heart function in patients suffering from beta-thalassemia major aged 5-10 years at the Zahedan Research Center for Children and Adolescent Health. Anatol J Cardiol. 2010; 10(2): 150-153


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