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Catheter-based renal sympathetic denervation induces acute renal inflammation through activation of caspase-1 and NLRP3 inflammasome [Anatol J Cardiol]
Anatol J Cardiol. Ahead of Print: AJC-62257 | DOI: 10.14744/AnatolJCardiol.2018.62257  

Catheter-based renal sympathetic denervation induces acute renal inflammation through activation of caspase-1 and NLRP3 inflammasome

Dong Won Lee1, Jeong-Su Kim2, Il Young Kim1, Hyang Sook Kim3, Joo-Young Kim3, Harin Rhee1, Eun Young Seong1, Sang Heon Song1, Soo Bong Lee1, Charles Louis Edelstein4
1Division of Nephrology, Department of Internal Medicine, Pusan National University School of Medicine, Busan, Republic of Korea
2Division of Cardiology, Department of Internal Medicine, Pusan National University, School of Medicine, Busan, Republic of Korea
3Research Institute for Convergence of Biomedical Science and Technology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea
4Division of Renal Diseases and Hypertension, University of Colorado Denver, Aurora, Colorado, USA

Objective: Catheter-based renal sympathetic denervation (RDN) is implemented as a strategy to treat resistant hypertension. Serum creatinine and estimated glomerular filtration rate (eGFR) have some limitations to predict the early stage of acute kidney injury (AKI). We investigated the changes of early inflammatory biomarkers in AKI following RDN procedure.
Methods: Twenty-five female swine were divided into 3 groups: normal control (Normal, n=5), sham-operated control (Sham, n=5), and RDN groups (RDN, n=15). The RDN group was further subdivided into 3 subgroups according to the time of sacrifice: immediately (RDN-0, n=5), 1 week (RDN-1, n=5), and 2 weeks (RDN-2, n=5) after RDN. We had renal cortical tissue harvested, and checked clinical parameters and inflammatory biomarkers.
Results: There were no significant changes in the clinical parameters between the normal control and sham-operated group using contrast-media. In the renal cortical tissue, inflammatory IL-1β, -18, -6, TNF-α, and anti-inflammatory IL-10 increased immediately, and then decreased at the second week after RDN. Leaderless protein, IL-1α increased at the first week, and then decreased at the second week after RDN. Caspase-1 increased immediately after RDN until the second week. ASC and NLRP3 expressions increased immediately, and then decreased at the second week after RDN.
Conclusion: The RDN could induce acute renal inflammation through activation of caspase-1 and NLRP3 inflammasome.

Keywords: acute kidney injury, caspases, hypertension, inflammasomes, renal sympathetic denervation




Corresponding Author: Dong Won Lee, South Korea


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