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Use of cardiac CT angiography imaging in an epidemiology study - the Methodology of the Multicenter AIDS Cohort Study cardiovascular disease substudy [Anatol J Cardiol]
Anatol J Cardiol. 2013; 13(3): 207-214 | DOI: 10.5152/akd.2013.065  

Use of cardiac CT angiography imaging in an epidemiology study - the Methodology of the Multicenter AIDS Cohort Study cardiovascular disease substudy

Yalçın Hacıoğlu1, Mohit Gupta1, Tae-Young Choi1, Richard T. George2, Christopher R. Deible3, Lisa P. Jacobson4
1Harbor UCLA Medical Center and the Los Angeles Biomedical Research Institute, Torrance, CA-USA
2Johns Hopkins University, School of Medicine, Baltimore, MD-USA
3University of Pittsburgh, School of Medicine, Pittsburgh, PA-USA
4Johns Hopkins Bloomberg School of Public Health, Baltimore, MD-USA

Objective: The methodology for use of cardiac CT angiography (CTA) in low risk populations is not well defined. In order to present a reference for future studies, we present CTA methodology that is being used in an epidemiology study- the Multicenter AIDS Cohort Study (MACS). Methods: The Multicenter AIDS Cohort Study (MACS) is an on-going multicenter prospective, observational cohort study. The MACS Cardiovascular Disease substudy plans to enroll 800 men (n= 575 HIV seropositive and n=225 HIV seronegative) age 40-70 years for coronary atherosclerosis imaging using cardiac CTA. The protocol includes heart rate (HR) optimization with beta blockers; use of proper field of view; scan length limitation; prospective ECG-gating using the lowest beam voltage possible. All scans are evaluated for presence, extent, and com- position of coronary atherosclerosis, left atrial volumes, left ventricular volume and mass and non-coronary cardiac pathology. Results: The first 498 participants had an average radiation dose of 2.5±1.6 milliSieverts (mSv) for the cardiac CTA study. Overall quality of scans was fair to excellent in 98.6% of studies. There were three significant adverse events-two allergic reactions to contrast and one subcutaneous contrast extravasation. Conclusion: Cardiac CTA was safe and afforded a low effective radiation exposure to these asymptomatic research participants and provides valuable cardiovascular endpoints for scientific analysis. The cardiac CTA methodology described here may serve as a reference for use in future epidemiology studies aiming to assess coronary atherosclerosis and cardiac anatomy in low risk populations while minimizing radiation exposure.

Keywords: CT angiography, radiation dose, epidemiological study


Yalçın Hacıoğlu, Mohit Gupta, Tae-Young Choi, Richard T. George, Christopher R. Deible, Lisa P. Jacobson. Use of cardiac CT angiography imaging in an epidemiology study - the Methodology of the Multicenter AIDS Cohort Study cardiovascular disease substudy. Anatol J Cardiol. 2013; 13(3): 207-214


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