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The Effects of Clarithromycin Treatment on Cardiac Events in Acute Coronary Syndrome Patients [Anatol J Cardiol]
Anatol J Cardiol. 2004; 4(3): 213-216

The Effects of Clarithromycin Treatment on Cardiac Events in Acute Coronary Syndrome Patients

Ozan Ütük1, Cevad Şekuri2, Özgür Bayturan1, Ali Rıza Bilge4, Hakan Tıkız5, Talat Tavlı4, Uğur Kemal Tezcan4
1Department of Cardiology, School of Medicine, Celal Bayar University, Manisa, Turkey
2Özel Kent Hastanesi, Kardiyoloji Kliniği, İzmir
3Department of Cardiology, School of Medicine, Celal Bayar University, Manisa, Turkey
4Celal Bayar Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Manisa
5Department of Cardiology Faculty of Medicine, University of Celal Bayar, Manisa

Objective: The assessment of short duration early clarithromycin treatment on major cardiac events in acute coronary syndrome patients Methods: One hundred and thirteen patients with acute coronary syndrome had been enrolled in the study in a prospective manner. Fifty-seven of 113 patients received peroral clarithromycin 1g/day for 14 days in addition to standard therapy. The remaining 56 patients were considered as control group. The treatment and control groups had similar major cardiac risk factors such as diabetes, hypertension, dyslipidemia and smoking habits. The occurrence of unstable angina pectoris, non-ST elevation myocardial infarction and ST elevation myocardial infarction was comparable in both groups. The use of thrombolytic therapy and glycoprotein IIb/IIIa receptor blockers administration was also similar in both groups. The patients were followed for major cardiac events for 6 months. Results: During the follow-up, no difference was observed between groups in the occurrence of unstable angina pectoris, myocardial infarction, the need for revascularization with percutaneous coronary intervention or cardiac surgery and cardiac death. We observed a reduction of myocardial infarction and cardiac death occurrence and an increase in the necessity of percutaneous interventions in the treatment group even though this difference did not reach statistical significance. Conclusion: No benefit of short duration early clarithromycin therapy was observed in the occurrence of major cardiac events in acute coronary syndromes. Studies with longer treatment and follow-up period using different antibiotics are necessary to elucidate the possible effect of antibiotics on major cardiac events in patients with acute coronary syndrome.

Keywords: Acute coronary syndrome, clarithromycin


Akut Koroner Sendromlu Hastalarda Klaritromisin Tedavisinin Kardiyak Olaylar Üzerine Etkisi

Ozan Ütük1, Cevad Şekuri2, Özgür Bayturan1, Ali Rıza Bilge4, Hakan Tıkız5, Talat Tavlı4, Uğur Kemal Tezcan4
1Department of Cardiology, School of Medicine, Celal Bayar University, Manisa, Turkey
2Özel Kent Hastanesi, Kardiyoloji Kliniği, İzmir
3Department of Cardiology, School of Medicine, Celal Bayar University, Manisa, Turkey
4Celal Bayar Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, Manisa
5Department of Cardiology Faculty of Medicine, University of Celal Bayar, Manisa

Anahtar Kelimeler: Akut koroner sendrom, klaritromisin


Ozan Ütük, Cevad Şekuri, Özgür Bayturan, Ali Rıza Bilge, Hakan Tıkız, Talat Tavlı, Uğur Kemal Tezcan. The Effects of Clarithromycin Treatment on Cardiac Events in Acute Coronary Syndrome Patients. Anatol J Cardiol. 2004; 4(3): 213-216


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