ISSN 2149-2263 | E-ISSN 2149-2271 Home      
 
Volume : 23 Issue : 2
Current Issue Archive Popular Article Ahead of Print

   
Quick Search





 
Effect of glycemic control on the progress of left ventricular hypertrophy and diastolic dysfunction in children with type I diabetes mellitus [Anatol J Cardiol]
Anatol J Cardiol. 2012; 12(6): 498-507 | DOI: 10.5152/akd.2012.158  

Effect of glycemic control on the progress of left ventricular hypertrophy and diastolic dysfunction in children with type I diabetes mellitus

Soha M. Abd El Dayem1, Ahmed A. Battah2
1Department of Pediatrics, National Research Centre, Cairo
2Department of Critical Care, Kasr El Ani Hospital, Cairo University, Cairo, Egypt

Objective: To evaluate progression of left ventricular (LV) structural and functional changes in patients with type 1 diabetes and effect of glycemic control on these changes. Methods: A prospective, longitudinal study consisted of 48 patients who were originally studied. At two years follow-up, 44 patients were reevaluated, 35 patients from the original study were reevaluated after another 2 years for the 3rd time using the same protocol. The control group comprised 30 age-and sex-matched healthy volunteers. All studied patients were subjected to full history taking, clinical and cardiac examination. M-mode echocardiography was done, blood samples were taken and examined for HbA1c and urine samples were tested for the presence of albuminuria. ANOVA for repeated measurements, t-test for dependent and independent variables, and Mann-Whitney U test were used for statistical analyses. Results: Seven (14.6%) of our patients had LV hypertrophy, 23 (47.9%) patients had diastolic dysfunction and ten patients only achieve improvement in glycemic control. Duration of diabetes was significantly higher in patients with LV hypertrophy (LVH) (p<0.05). Patients with no improvement in glycemic control had a significant increase in interventricular septum (IVS) and left ventricular posterior wall (LVPW) in the third examination (p<0.05 for both). Conclusion: Prevalence of LVH and diastolic dysfunction among diabetic patients is high. Glycemic control in diabetic patients could not improve LVH or diastolic dysfunction. On the other hand, failure to achieve glycemic control leads to deterioration in structural parameters.

Keywords: Glycemic control, echocardiography, progression, insulin-dependent diabetes mellitus, left ventricular hypertrophy, diastolic dysfunction


Soha M. Abd El Dayem, Ahmed A. Battah. Effect of glycemic control on the progress of left ventricular hypertrophy and diastolic dysfunction in children with type I diabetes mellitus. Anatol J Cardiol. 2012; 12(6): 498-507


TOOLS
Full Text PDF
Print
Download citation
RIS
EndNote
BibTex
Medlars
Procite
Reference Manager
Share with email
Share


Similar articles
PubMed
Google Scholar




 
 
KARE Publishing | Copyright 2018 Turkish Society of Cardiology