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Ischemia-modified albumin and total antioxidant status in patients with slow coronary flow: a pilot observational study [Anatol J Cardiol]
Anatol J Cardiol. 2011; 11(7): 582-587 | DOI: 10.5152/akd.2011.159  

Ischemia-modified albumin and total antioxidant status in patients with slow coronary flow: a pilot observational study

Fatih Koç1, Sami Erdem2, Fatih Altunkaş3, Kerem Özbek4, Enes Elvin Gül5, Sevil Kurban1, Erkan Taşyürek1, Ekrem Erbay8, Erkan Söğüt9
1Gaziosmanpaşa Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, 60100 Tokat-Türkiye
2Department of Cardiology, Faculty of Medicine, Selçuk University, Konya-Turkey
3Department of Cardiology, Faculty of Medicine, Gaziosmanpaşa University, Tokat, Turkey
4Department of Cardiology, Faculty of Medicine, Gaziosmanpaşa University, Tokat-Turkey
5Department of Cardiology, Meram School of Medicine, Selçuk University, Konya-Turkey
6Gaziosmanpaşa Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, 60100 Tokat-Türkiye
7Gaziosmanpaşa Üniversitesi Tıp Fakültesi, Kardiyoloji Anabilim Dalı, 60100 Tokat-Türkiye
8Department of Biochemistry, Faculty of Medicine, Selçuk University, Konya-Turkey
9Department of Biochemistry, Faculty of Medicine, Gaziosmanpaşa University, Tokat

Objective: Slow coronary flow (SCF) is defined as late opacification in the epicardial coronary arteries without significant stenosis. The underlying mechanism of SCF is similar to coronary atherosclerosis. Free radical damage may be responsible for the pathology. In this study, we aimed to investigate ischemia-modified albumin (IMA) levels and differences with regard to total antioxidant status (TAS) between patients with normal coronary arteries and patients with SCF without significant stenosis. Methods: Thirty patients who were diagnosed with SCF using coronary angiography were included in this cross-sectional observational study (13 male; mean age, 56±10 years). The control group consisted of 30 patients who had normal coronary arteries as shown by coronary angiography (13 male; mean age, 53±11 years). In this study, we assessed serum IMA levels, albumin-adjusted IMA and TAS. The Student t-test was used to compare serum IMA levels and TAS between the two groups. Pearson’s correlation test was used to explore the relationship between TAS and serum IMA levels. Results: Serum IMA levels and albumin-adjusted IMA were similar in both groups (p=0.432, p=0.349). The mean value of TAS was significantly lower in the SCF group compared to control group (p=0.011). The TAS was negatively correlated with the levels of IMA and albumin-adjusted IMA in the SCF group (r=-0.457, p=0.011; r=-0.509, p=0.004). Conclusion: This study shows that serum IMA levels and albumin-adjusted IMA were similar between the groups, however the mean value of TAS was significantly lower in the SCF group compared to control group and negatively correlated with IMA. These results are important in terms of understanding the pathophysiological basis of SCF.

Keywords: Antioxidant status, ischemia-modified albumin, slow coronary flow


Fatih Koç, Sami Erdem, Fatih Altunkaş, Kerem Özbek, Enes Elvin Gül, Sevil Kurban, Erkan Taşyürek, Ekrem Erbay, Erkan Söğüt. Ischemia-modified albumin and total antioxidant status in patients with slow coronary flow: a pilot observational study. Anatol J Cardiol. 2011; 11(7): 582-587


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