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Long-term graft patency after coronary artery bypass grafting: Effects of morphological and pathophysiological factors [Anatol J Cardiol]
Anatol J Cardiol. 2018; 20(5): 275-282 | DOI: 10.14744/AnatolJCardiol.2018.51447  

Long-term graft patency after coronary artery bypass grafting: Effects of morphological and pathophysiological factors

Grigore Tinica1, Raluca Ozana Chistol2, Mihail Enache1, Maria Magdalena Leon Constantin3, Manuela Ciocoiu4, Cristina Furnica5
1Department of Cardiovascular Surgery, “Prof. Dr. George I.M. Georgescu” Cardiovascular Diseases Institute; Department of Cardiac Surgery, “Grigore T. Popa” University of Medicine and Pharmacy; Iasi-Romania
2Department of Medical Imaging, “Prof. Dr. George I.M. Georgescu” Cardiovascular Diseases Institute; Iasi-Romania
3Department of Medical Rehabilitation, Clinical Rehabilitation Hospital; Department of Internal Medicine, “Grigore T. Popa” University of Medicine and Pharmacy; Iasi-Romania
4Department of Physiopathology, “Grigore T. Popa” University of Medicine and Pharmacy; Iasi-Romania
5Institute of Forensic Medicine; Department of Anatomy, “Grigore T. Popa” University of Medicine and Pharmacy; Iasi-Romania

Objective: The aim of the present study was to identify morphological and pathophysiological factors associated with long-term patency of grafts used in coronary artery bypass grafting (CABG).
Methods: A total of 127 patients who underwent CABG between 2000 and 2006 and presented for computed tomography evaluation of graft patency at 139.78±36.64 months post-CABG were analyzed. Patients received 340 grafts (2.68 grafts/patient), 399 distal anastomoses (3.14 anastomoses/patient), 220 (55.14%) performed using arterial grafts, and 179 (44.86%) using saphenous vein grafts (SVGs).
Results: Graft patency varied according to vessel type and coronary territory. Overall graft patency was 90.16% for the left internal thoracic artery (LITA), 75.55% for the right internal thoracic artery (RITA), 79.25% for the radial artery (RA), and 74.3% for the SVG. The maximum patency rate was obtained with the RA (80.65%) for the right coronary territory, RITA (92.86%) for the anterolateral territory, and SVG (82.54%) for the circumflex territory. The LITA–left anterior descending artery graft occluded in 13 (7.93%) cases, 7 due to competitive flow. The influence of graft length on patency rates after indexing to height was not significant. The target vessel degree of stenosis influenced arterial graft patency rates with an occlusion odds ratio (OR) of 3.02 when anastomosed to target vessels with <90% stenosis. Target vessel caliber also influenced patency rates with occlusion ORs of 2.63 for SVGs and 2.31 for arterial grafts when anastomosed to ≤1.5 mm target vessels.
Conclusion: Morphological parameters, such as graft type, target territory, target vessel caliber, and degree of stenosis, are important factors conditioning long-term graft patency.

Keywords: coronary artery bypass grafting, long-term patency, morphological factors, pathophysiological factors


Grigore Tinica, Raluca Ozana Chistol, Mihail Enache, Maria Magdalena Leon Constantin, Manuela Ciocoiu, Cristina Furnica. Long-term graft patency after coronary artery bypass grafting: Effects of morphological and pathophysiological factors. Anatol J Cardiol. 2018; 20(5): 275-282

Corresponding Author: Raluca Ozana Chistol, Romania


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